Pooled platelet concentrates provide a small benefit over single-donor platelets for patients with platelet refractoriness of any etiology [PDF]
Journal of International Medical Research, 2021 Background At our institution, patients with platelet refractoriness (of any etiology) are sometimes switched from apheresis platelets to pooled platelets before human leukocyte antigen (HLA)-matched units become available. Study design and methods Seven
Ying-Hsia Chu +3 more
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Identification of platelet refractoriness in oncohematologic patients [PDF]
Clinics, 2011 OBJECTIVES: To identify the occurrence and the causes of platelet refractoriness in oncohematologic patients. INTRODUCTION: Platelet refractoriness (unsatisfactory post-transfusion platelet increment) is a severe problem that impairs the treatment of ...
Aline Aparecida Ferreira +4 more
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Prevalence of platelet reactive antibodies in patient′s refractory to platelet transfusions
Asian Journal of Transfusion Science, 2014 Introduction & Aims: Though platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders, refractoriness to infused platelets becomes a major ...
Nitin Agarwal +3 more
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Immunological platelet transfusion refractoriness: current insights from mechanisms to therapeutics
PlateletsAlthough there have been tremendous improvements in the production and storage of platelets, platelet transfusion refractoriness (PTR) remains a serious clinical issue that may lead to various severe adverse events.
Xiaoyu Chen +3 more
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Perioperative administration of recombinant activated factor VII in a Glanzmannʼs thrombasthenia patient with platelet refractoriness: case report [PDF]
Brazilian Journal of Anesthesiology, 2022 Glanzmannʼs Trombasthenia (GT) is a genetic disorder, that develops with a tendency toward bleeding and is characterized by the absence or decrease in platelet aggregation. Surgical bleeding may be difficult to control.
Flora Margarida Barra Bisinotto +3 more
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Platelet antibody detection by flow cytometry: an effective method to evaluate and give transfusional support in platelet refractoriness [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2013 BACKGROUND: Immune platelet refractoriness is mainly caused by human leukocyte antigen antibodies (80-90% of cases) and, to a lesser extent, by human platelet antigen antibodies.
Carolina Bonet Bub +5 more
doaj +4 more sources
Macrophages are key mediators of platelet refractoriness [PDF]
Blood AdvancesBarbara Pelham-Webb, Elizabeth F. Stone
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Global Journal of Transfusion Medicine, 2019 Platelet transfusion support is extensively required for hemato-oncology patients who are multiply transfused. Platelet refractoriness can represent a significant clinical condition that complicates the platelet transfusion support in such patients.
B Sunil Rajadhyaksha +2 more
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Platelet Transfusion Refractoriness [PDF]
British Journal of Haematology, 2008 Summary The platelet, a fascinating anucleate cell, is critically important for haemostasis. Platelet transfusions have greatly reduced the incidence of major haemorrhagic complications associated with the management of haematological and oncological disorders.
Eldad A Hod, Joseph E. Schwartz
exaly +3 more sources
Anti-HLA antibody formation increases the chances of platelet refractoriness in platelet-transfused patients: a systematic review with meta-analysis [PDF]
Hematology, Transfusion and Cell TherapyPlatelet refractoriness caused by alloimmunization to anti-HLA antibodies remains present in daily hemotherapy: the frequent need for platelet transfusions may influence the long-term survival of treated patients. This study aimed to perform a systematic
Luana Joana Barreto Cabral +5 more
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