Results 101 to 110 of about 125,579 (360)

Ultrasound‐Boosted Liposomal Prodrug Overcomes Age‐Associated Biodistribution Disparity in Pediatric Solid Tumor Therapy

Advanced Science, EarlyView.
The age‐associated disparity of nanocarrier biodistribution limits the nanotherapeutics of childhood solid tumors. This study developed an ultrasound‐activated liposomal prodrug (CSCPTL) to overcome the age‐associated disparity of off‐target distribution.
Danfei Chen, Junjun Xu, Jian Chen, Jue Hu, Xiaobo Xuan, Haifang Cai, Mingdong Yang, Zhuxian Zhou, Guowei Wang   +8 more
wiley   +1 more source

Prognostic value of pretreatment inflammatory biomarkers in patients with laryngeal cancer

Asian Journal of Surgery
Summary: Objectives: The systemic inflammatory response is strongly involved in the progression of malignant tumors, and it is useful for predicting survival time and determining therapeutic effects. The inflammatory biomarkers, neutrophil-to-lymphocyte
Toshiaki Kawano, Takashi Hirano, Kaori Tateyama, Kazuhiro Yoshinaga, Kaori Shinomura, Masashi Suzuki   +5 more
doaj   +1 more source

Role of splenectomy in human liver transplantation under modern-day immunosuppression [PDF]

, 1998
Between January 1987 and October 1991, 1466 patients underwent consecutive Orthotopic Liver Transplantation (OLTx) at the University of Pittsburgh. Forty of these patient's had concomitant splenectomy with OLTx.
Demetris, AJ, Eghtesad, B, Fung, JJ, Irish, WD, Samimi, F, Starzl, TE   +5 more
core   +1 more source

Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial. [PDF]

, 2020
BACKGROUND:Zinc deficiency impairs immune function and is common among children in South-East Asia. OBJECTIVES:The effect of zinc supplementation on immune function in young Laotian children was investigated.
Andreini, Anzilotti, Barffour, Beck, Black, Boulay, Brown, Butt, Castillo-Duran, Charles B Stephensen, Chidchamai Kewcharoenwong, Gammoh, Ganjana Lertmemongkolchai, Gertrud U Schuster, Gibson, Guy-Marino Hinnouho, Haase, Hojyo, Honscheid, International Zinc Nutrition Consultative Group, International Zinc Nutrition Consultative Group, Inthira Tussakhon, Janet M Peerson, Jia, K Ryan Wessells, Kenneth H Brown, King, Lu, Maizels, Maxwell A Barffour, Mayo-Wilson, Maywald, Mehta, Prasad, Rajamanickam, Raqib, Ravin, Richter, Rosenkranz, Rosenkranz, Sandstead, Sazawal, Sengchanh Kounnavong, Sheikh, Shi, Sonja Y Hess, Tahan, Tepaamorndech, Walker, Wan, Waraporn Samer, Wessells, Wessells, WHO, Wu   +54 more
core   +2 more sources

Neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in anorectal abscess

Turkish Journal of Trauma and Emergency Surgery, 2021
Rujittika, Mungmunpuntipantip, Viroj, Wiwanitkit   +1 more
openaire   +2 more sources

Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as predictors of refractory anaphylaxis

World Allergy Organization Journal
Refractory anaphylaxis poses an ongoing, lethal hypersensitivity response that unpredictably involves multiple organs despite appropriate intramuscular (IM) adrenaline injections. Studies on the association of the platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) concerning anaphylactic severity have yet to be carried out. The
Le Vinh Nghi, Nguyen Hoang Phuc, Pham Dang Hai   +2 more
openaire   +3 more sources

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Assessing the Predictive Value of Haematological Parameters (NLR, LMR, PLR) for COVID-19 Disease Severity as quantified by CT Severity Scores: A Prospective Cohort Study [PDF]

Journal of Clinical and Diagnostic Research
Introduction: In the relentless global battle against the Coronavirus Disease-2019 (COVID-19) pandemic, accurate prediction of disease severity remains a critical challenge, with profound implications for patient outcomes and healthcare resource ...
Kovuri Umadevi, Lavanya Motrapu, Kasturi Dinesh, Nagarjuna Chary Rajarikam, Mohd Imran Ali   +4 more
doaj   +1 more source

Combined Photothermal and mTOR‐Targeted Therapy Overcomes Immune Evasion and Enhances Checkpoint Blockade Efficacy in Metastatic Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study reveals that photothermal therapy, while inducing immunogenic cell death in triple‐negative breast cancer, paradoxically activates the oncogenic mTOR pathway to drive immune evasion. To counter this, a smart nanocomposite is engineered to co‐deliver localized hyperthermia and mTOR inhibition.
Yujie Zhao, Jing Yu, Xin Wang, Xu Liu, Fengli Zuo, Tianyue Xu, Leyi Tang, Ling Xiong, Li Li, Huifang Li, Xiaoting Chen, Guang Yang, Jing Jing, Xiaowei Liu   +13 more
wiley   +1 more source

Platelet-to-albumin ratio and radiation-induced lymphopenia—prognostic biomarker for carcinoma esophagus

Journal of the Egyptian National Cancer Institute
Background Esophageal cancer has a poor survival outcome with 5-year OS at 16.7% despite treatment. Some inflammation-based prognostic indicators like the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously ...
Adrija Ghosh, Abhilash Dagar, Ram Pukar Bharat, Jaswin Raj, Dyuti Shah, Jyoti Sharma, Akash Kumar, Pritee A. Patil, Aman Sharma, Dayanand Sharma, Supriya Mallick   +10 more
doaj   +1 more source