Results 191 to 200 of about 48,011 (239)

Causes of refractoriness to platelet transfusion

Current Opinion in Hematology, 1995
Platelet refractoriness is a multifactorial problem that often leads to aggressive measures in an attempt to treat a thrombocytopenic patient. Identification of the underlying causes should allow for prevention and management regimens to improve both transfusion practice and patient outcome.
R C, Friedberg, P D, Mintz
openaire   +2 more sources

Platelet transfusions: The problem of refractoriness

Blood Reviews, 1990
Refractoriness is a complication of multiple platelet transfusions in 30-70% of patients with bone marrow failure. The major causes are HLA alloimmunisation and non-immune platelet consumption; the latter is usually found in patients with DIC, septicaemia or splenomegaly.
M F, Murphy, A H, Waters
openaire   +2 more sources

Factors influencing platelet transfusion refractoriness in patients undergoing allogeneic hematopoietic stem cell transplantation

Annals of Hematology, 2017
Pilar Solves, Jaime Sanz, JOSÉ Luis Pinana   +2 more
exaly   +2 more sources

Efficacy of HLA virtual cross‐matched platelet transfusions for platelet transfusion refractoriness in hematopoietic stem cell transplantation

Transfusion, 2020
Cross‐matched platelet (cross‐matched PLT) transfusion is effective for immune‐mediated platelet transfusion refractoriness (PTR), but is more costly and time‐consuming for physical cross‐match than using standard PLT units.
K. Seike, N. Fujii, Naomi Asano, S. Ohkuma, Yasushi Hirata, K. Fujii, Y. Sando, Makoto Nakamura, K. Naito, Kyosuke Saeki, Yusuke Meguri, N. Asada, D. Ennishi, H. Nishimori, K. Matsuoka, K. Tsubaki, F. Otsuka, Y. Maeda   +17 more
semanticscholar   +1 more source

Targeting CD38 with Daratumumab for Platelet Transfusion Refractoriness in Aplastic Anemia.

Blood
We found that 8 out of 10 aplastic anemia patients experienced resolution of platelet transfusion refractoriness following daratumumab administration. Notably, 4 responders achieved hematopoietic recovery, including 3 participants showed improvements in ...
Zhenyuan Gao, H. Pan, Lele Zhang, Weiwang Li, Ruonan Li, Jingyu Zhao, Yuechen Luo, Yu Lian, Xiao Yu, Zhexiang Kuang, N. Nie, Jianping Li, Jinbo Huang, Xin Zhao, Yuan Li, Liwei Fang, M. Ge, Yizhou Zheng, Jun Shi   +18 more
semanticscholar   +1 more source

Refractoriness to platelet transfusion

Current Opinion in Hematology, 2002
This review discusses the causes of refractoriness to platelet transfusions and presents three options for its management. Platelet refractoriness is a complication of platelet transfusion that affects variable proportions of patients, mostly depending on their diagnosis, previous immunologic stimuli, and type of blood products used for transfusion.
openaire   +2 more sources

Management of Patients Refractory to Platelet Transfusion

Journal of Infusion Nursing, 2007
This article discusses the causes and management of platelet refractoriness. Improvements in the quality of platelets and leukoreduction have reduced the morbidity and mortality related to alloimmunization and refractoriness of patients to platelet transfusion.
Porselvi, Chockalingam, Ronald A, Sacher
openaire   +2 more sources

Successful use of rituximab in platelet transfusion refractoriness in a multi-transfused patient with myelodysplastic syndrome

Platelets, 2015
Yu-Hong Zhou
exaly   +2 more sources

Virtual platelet cross‐matching as transfusion management for patients with immune platelet refractoriness

Vox Sanguinis, 2023
This study describes the use of the Epvix platform for virtual cross‐matching (VC) of human leucocyte antigen (HLA)‐compatible platelets for patients with immune platelet refractoriness, and demonstrates effectiveness of the selected platelets.
Carolina Bonet-Bub, B. P. Blanco, T. C. de Oliveira, Tamiris Baptista Sampaio, Í. Gomes, Valéria de Freitas Dutra, T. Costa, J. Kutner   +7 more
semanticscholar   +1 more source

Alloimmune refractoriness to platelet transfusions

Current Opinion in Hematology, 1997
Patients who are transfused on multiple occasions with red cells or platelets may develop platelet-reactive alloantibodies and experience decreased clinical responsiveness to platelet transfusion. This situation, conventionally described as "refractoriness to platelet transfusions," is defined by an unsatisfactory low post-transfusion platelet count ...
openaire   +2 more sources