Results 181 to 190 of about 48,011 (239)

Platelet transfusion refractoriness and anti‐HLA immunization

Transfusion, 2021
AbstractPlatelet transfusion refractoriness (PTR), defined as an unsatisfactory post‐transfusion platelet count increment, is a common complication of patients receiving multiple transfusions. Different strategies are described in the management of PTR. In this work, we demonstrate the efficacy of the detection and identification of anti‐HLA antibodies
Lucie Blandin, Amandine Fayard, Jacques-Olivier Bay   +2 more
exaly   +4 more sources

Platelet transfusion: Alloimmunization and refractoriness

Seminars in Hematology, 2020
The transfusion of platelets for both prophylaxis and treatment of bleeding is relevant to all areas of medicine and surgery. Historically, guidance regarding platelet transfusion has been limited by a lack of good quality clinical trials and so has been based largely on expert opinion. In recent years however there has been renewed interest in methods
Alexandros Rampotas, Lise J Estcourt, Simon J Stanworth   +2 more
exaly   +4 more sources

A Patient with Platelet Transfusion Refractoriness

Malaysian Journal of Science
Abstract Platelet transfusion refractoriness is a less-than-expected increase in platelet count following platelet transfusions. We report a case of platelet transfusion refractoriness with identification of anti-HLA class I alloantibody. In patients with thrombocytopenia, even when multiple established aetiologies are present, it is essential to ...
Wint Wint Thu Nyunt, Rabeya Yousuf, S Fadilah S Abdul Wahid   +2 more
openaire   +2 more sources

Complement as an Immune Barrier in Platelet Transfusion Refractoriness

Transfusion Medicine Reviews, 2019
Patients with hematological cancers often have low platelet counts because of progressing bone marrow failure or cytostatic therapy. A large fraction of those patients need platelet transfusions, which can be life-saving if bleedings occur and also allow diagnostic and therapeutic interventions. The outcomes of platelet transfusions are not always easy
Stephan, Meinke, Cecilia, Karlström, Petter, Höglund   +2 more
openaire   +3 more sources

Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management

Blood Reviews, 2023
Platelet transfusion refractoriness due HLA alloimmunization presents a significant medical problem, particularly among multiply transfused patients with hematologic malignancies and those undergoing hematopoietic stem cell transplants.
Sandhya R Panch, Ralph R Vassallo
exaly   +2 more sources

Severe Platelet Transfusion Refractoriness in Association with Antibodies Against CD36

Laboratory Medicine, 2020
Platelet-transfusion refractoriness (PTR) is common in patients with hematological malignancies. The etiology of immune PTR is typically human leukocyte antigen (HLA) antibodies (Abs) from pregnancy or previous transfusion.
Amy E Schmidt, Majed A Refaai, Refaai Majed A   +2 more
exaly   +2 more sources

Non-Alloimmune Mechanisms of Thrombocytopenia and Refractoriness to Platelet Transfusion

Transfusion Medicine Reviews, 2020
Refractoriness to platelet transfusion is a common clinical problem encountered by the transfusion medicine specialist. It is well recognized that most causes of refractoriness to platelet transfusion are not a consequence of alloimmunization to human ...
Roger Belizaire
exaly   +2 more sources

The definition of refractoriness to platelet transfusions

Transfusion Medicine, 1992
SUMMARY. The relationship between the 1 and 20 h post‐transfusion platelet count and three parameters used to define refractory transfusions, namely the corrected increment (CI), platelet increment (PI), and percentage platelet recovery (%REC), was studied in 437 non‐HLA matched platelet transfusions given to 102 patients with bone marrow failure. The
J F, Bishop, J P, Matthews, K, Yuen, K, McGrath, M M, Wolf, J, Szer   +5 more
openaire   +2 more sources