Results 181 to 190 of about 3,449 (222)

The definition of refractoriness to platelet transfusions

Transfusion Medicine, 1992
SUMMARY. The relationship between the 1 and 20 h post‐transfusion platelet count and three parameters used to define refractory transfusions, namely the corrected increment (CI), platelet increment (PI), and percentage platelet recovery (%REC), was studied in 437 non‐HLA matched platelet transfusions given to 102 patients with bone marrow failure. The
J F, Bishop, J P, Matthews, K, Yuen, K, McGrath, M M, Wolf, J, Szer   +5 more
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Platelet Transfusion Refractory Patients

2009
Publisher Summary This chapter focuses on an inappropriately low platelet count defined as platelet refractory, which develops following repeated platelet transfusions. The cause for platelet refractoriness is mentioned to be both non-immune and immune and etiology is often multifactorial.
Jeanne E. Hendrickson, John D. Roback
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Management of Patients Refractory to Platelet Transfusion

Journal of Infusion Nursing, 2007
This article discusses the causes and management of platelet refractoriness. Improvements in the quality of platelets and leukoreduction have reduced the morbidity and mortality related to alloimmunization and refractoriness of patients to platelet transfusion.
Porselvi, Chockalingam, Ronald A, Sacher
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Transfusion of ABO‐mismatched platelets leads to early platelet refractoriness

British Journal of Haematology, 1990
Summary. Forty‐three consecutive patients previously unexposed to platelets and undergoing treatment for acute leukaemia or autografting for relapsed Hodgkin's lymphoma were randomized to receive transfused platelets of either their own ABO group (OG) or of a major mismatched group (MMG).
R, Carr, J L, Hutton, J A, Jenkins, G F, Lucas, N W, Amphlett   +4 more
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Refractory Response to Platelet Transfusion Therapy

Journal of Infusion Nursing, 2010
Platelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can contribute to a poor posttransfusion increment, refractoriness is typically defined as failure to achieve an appropriate increment after receiving 2 consecutive transfusions ...
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Antileukocyte Antibodies in Patients Refractory to Platelet Transfusions

American Journal of Clinical Pathology, 1979
Sera from 12 multitransfused patients who were refractory to random-donor platelets were tested for lymphocytotoxic and leukoagglutinating antibodies using panel cells from various volunteers whose HLA-A and -B antigens were known. All sera contained leukoagglutinins reactive with cells from at least one panel member, whereas only 33% had ...
B R, MacPherson, R G, Westphal
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HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model

Human Gene Therapy, 2013
Refractoriness to platelet (PLT) transfusion caused by alloimmunization against HLA class I antigens constitutes a significant clinical problem. Thus, it would be desirable to have PLT units lacking HLA antigens on the cell surface. Previously, we showed that the generation of functional HLA class I-silenced (HLA-universal) PLTs from CD34(+) cells ...
Christiane, Gras, Kai, Schulze, Lilia, Goudeva, Carlos A, Guzman, Rainer, Blasczyk, Constança, Figueiredo   +5 more
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Extended platelet transfusion in bleeding patients with platelet transfusion refractoriness

Transfusion and Apheresis Science, 2023
Tatiana, Fernández-Barge, Juan J, Domínguez-García, Alba, Díaz-Santander, Raquel, Rivero-Fernández, Rodrigo, Cantera-Estefanía, Gala A, Mendez, Íñigo, Romón   +6 more
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Alloimmunization and Refractoriness to Platelet Transfusions

Laboratory Medicine, 1992
Refractoriness to platelet transfusions due to alloimmunization is one of the most serious complications that can occur for a chronically transfused platelet recipient. Although the diagnosis and management of this condition are difficult, the available therapeutic choices are increasing. The increasing use of family and human leukocyte antigen–matched
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Refractoriness to Platelet Transfusions in Children with Acute Leukemia

Journal of Pediatric Hematology/Oncology, 1995
We evaluated the incidence of clinically significant refractoriness to platelet transfusions in children with acute leukemia.We reviewed the complete transfusion records up to July 1993 of all 213 patients diagnosed with acute leukemia at our institution over the 4-year period 1987 to 1990.
J, DeCoteau, S, Haddad, V, Blanchette, A, Poon   +3 more
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