Results 161 to 170 of about 2,118 (199)

Refractoriness to Platelet Transfusions in Children with Acute Leukemia

Journal of Pediatric Hematology/Oncology, 1995
We evaluated the incidence of clinically significant refractoriness to platelet transfusions in children with acute leukemia.We reviewed the complete transfusion records up to July 1993 of all 213 patients diagnosed with acute leukemia at our institution over the 4-year period 1987 to 1990.
J, DeCoteau, S, Haddad, V, Blanchette, A, Poon   +3 more
openaire   +2 more sources

Diagnosis and management of refractoriness to platelet transfusion

Blood Reviews, 2001
Improvements in the availability and quality of platelet transfusions have markedly reduced the morbidity and mortality associated with intensive myelosuppressive therapy. Alloimmunization and refractoriness to platelet transfusion remains a significant clinical problem, although the incidence of alloimmunization may be declining due to more widespread
openaire   +2 more sources

Platelet Transfusion Refractory Patients

2009
Publisher Summary This chapter focuses on an inappropriately low platelet count defined as platelet refractory, which develops following repeated platelet transfusions. The cause for platelet refractoriness is mentioned to be both non-immune and immune and etiology is often multifactorial.
Jeanne E. Hendrickson, John D. Roback
openaire   +1 more source

Antileukocyte Antibodies in Patients Refractory to Platelet Transfusions

American Journal of Clinical Pathology, 1979
Sera from 12 multitransfused patients who were refractory to random-donor platelets were tested for lymphocytotoxic and leukoagglutinating antibodies using panel cells from various volunteers whose HLA-A and -B antigens were known. All sera contained leukoagglutinins reactive with cells from at least one panel member, whereas only 33% had ...
B R, MacPherson, R G, Westphal
openaire   +2 more sources

A Patient with Platelet Transfusion Refractoriness

Malaysian Journal of Science
Abstract Platelet transfusion refractoriness is a less-than-expected increase in platelet count following platelet transfusions. We report a case of platelet transfusion refractoriness with identification of anti-HLA class I alloantibody. In patients with thrombocytopenia, even when multiple established aetiologies are present, it is essential to ...
Wint Wint Thu Nyunt, Rabeya Yousuf, S Fadilah S Abdul Wahid   +2 more
openaire   +1 more source

Alloimmunization and Refractoriness to Platelet Transfusions

Laboratory Medicine, 1992
Refractoriness to platelet transfusions due to alloimmunization is one of the most serious complications that can occur for a chronically transfused platelet recipient. Although the diagnosis and management of this condition are difficult, the available therapeutic choices are increasing. The increasing use of family and human leukocyte antigen–matched
openaire   +1 more source

Complement as an Immune Barrier in Platelet Transfusion Refractoriness

Transfusion Medicine Reviews, 2019
Patients with hematological cancers often have low platelet counts because of progressing bone marrow failure or cytostatic therapy. A large fraction of those patients need platelet transfusions, which can be life-saving if bleedings occur and also allow diagnostic and therapeutic interventions. The outcomes of platelet transfusions are not always easy
Stephan, Meinke, Cecilia, Karlström, Petter, Höglund   +2 more
openaire   +2 more sources

Transfusion of ABO‐mismatched platelets leads to early platelet refractoriness

British Journal of Haematology, 1990
Summary. Forty‐three consecutive patients previously unexposed to platelets and undergoing treatment for acute leukaemia or autografting for relapsed Hodgkin's lymphoma were randomized to receive transfused platelets of either their own ABO group (OG) or of a major mismatched group (MMG).
R, Carr, J L, Hutton, J A, Jenkins, G F, Lucas, N W, Amphlett   +4 more
openaire   +2 more sources

Extended platelet transfusion in bleeding patients with platelet transfusion refractoriness

Transfusion and Apheresis Science, 2023
Tatiana, Fernández-Barge, Juan J, Domínguez-García, Alba, Díaz-Santander, Raquel, Rivero-Fernández, Rodrigo, Cantera-Estefanía, Gala A, Mendez, Íñigo, Romón   +6 more
openaire   +2 more sources

Alloimmunization and Platelet Transfusion Refractoriness

1993
Since over 20 years platelet transfusions are established therapy allowing prolonged survival of patients with hematologic and hemato-oncologic diseases.
openaire   +1 more source