Results 151 to 160 of about 2,118 (199)

Platelet transfusion: Alloimmunization and refractoriness

Seminars in Hematology, 2020
The transfusion of platelets for both prophylaxis and treatment of bleeding is relevant to all areas of medicine and surgery. Historically, guidance regarding platelet transfusion has been limited by a lack of good quality clinical trials and so has been based largely on expert opinion. In recent years however there has been renewed interest in methods
Michael Murphy, Alexandros Rampotas, Simon J Stanworth   +2 more
exaly   +3 more sources

Platelet transfusion refractoriness and anti‐HLA immunization

Transfusion, 2021
AbstractPlatelet transfusion refractoriness (PTR), defined as an unsatisfactory post‐transfusion platelet count increment, is a common complication of patients receiving multiple transfusions. Different strategies are described in the management of PTR. In this work, we demonstrate the efficacy of the detection and identification of anti‐HLA antibodies
Paul Rouzaire
exaly   +3 more sources

The definition of refractoriness to platelet transfusions

Transfusion Medicine, 1992
SUMMARY. The relationship between the 1 and 20 h post‐transfusion platelet count and three parameters used to define refractory transfusions, namely the corrected increment (CI), platelet increment (PI), and percentage platelet recovery (%REC), was studied in 437 non‐HLA matched platelet transfusions given to 102 patients with bone marrow failure. The
J F, Bishop, J P, Matthews, K, Yuen, K, McGrath, M M, Wolf, J, Szer   +5 more
openaire   +2 more sources

Causes of refractoriness to platelet transfusion

Current Opinion in Hematology, 1995
Platelet refractoriness is a multifactorial problem that often leads to aggressive measures in an attempt to treat a thrombocytopenic patient. Identification of the underlying causes should allow for prevention and management regimens to improve both transfusion practice and patient outcome.
R C, Friedberg, P D, Mintz
openaire   +2 more sources

Platelet transfusions: The problem of refractoriness

Blood Reviews, 1990
Refractoriness is a complication of multiple platelet transfusions in 30-70% of patients with bone marrow failure. The major causes are HLA alloimmunisation and non-immune platelet consumption; the latter is usually found in patients with DIC, septicaemia or splenomegaly.
M F, Murphy, A H, Waters
openaire   +2 more sources

Refractoriness to platelet transfusion

Current Opinion in Hematology, 2002
This review discusses the causes of refractoriness to platelet transfusions and presents three options for its management. Platelet refractoriness is a complication of platelet transfusion that affects variable proportions of patients, mostly depending on their diagnosis, previous immunologic stimuli, and type of blood products used for transfusion.
openaire   +2 more sources

Management of Patients Refractory to Platelet Transfusion

Journal of Infusion Nursing, 2007
This article discusses the causes and management of platelet refractoriness. Improvements in the quality of platelets and leukoreduction have reduced the morbidity and mortality related to alloimmunization and refractoriness of patients to platelet transfusion.
Porselvi, Chockalingam, Ronald A, Sacher
openaire   +2 more sources

Alloimmune refractoriness to platelet transfusions

Current Opinion in Hematology, 1997
Patients who are transfused on multiple occasions with red cells or platelets may develop platelet-reactive alloantibodies and experience decreased clinical responsiveness to platelet transfusion. This situation, conventionally described as "refractoriness to platelet transfusions," is defined by an unsatisfactory low post-transfusion platelet count ...
openaire   +2 more sources

Refractory Response to Platelet Transfusion Therapy

Journal of Infusion Nursing, 2010
Platelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can contribute to a poor posttransfusion increment, refractoriness is typically defined as failure to achieve an appropriate increment after receiving 2 consecutive transfusions ...
openaire   +2 more sources

ABH antibodies causing platelet transfusion refractoriness

Transfusion, 1986
Two alloimmunized patients with multispecific anti‐HLA and high‐titered ABH antibodies showed transfusion failures after ABH‐mismatched HLA‐identical platelet transfusions, whereas ABH‐matched HLA‐identical platelets showed sufficient increments. The anti‐A and ‐B could be demonstrated on platelets by immunofluorescence tests using FITC‐labeled goat ...
A, Brand, K, Sintnicolaas, F H, Claas, J G, Eernisse   +3 more
openaire   +2 more sources