Results 131 to 140 of about 291,220 (220)

Successful Management of Severe Hepatic Acute Graft‐Versus‐Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation in a Child With β‐Thalassemia Major: Clinical Lessons From Early Therapeutic Escalation

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Severe hepatic acute graft‐versus‐host disease can occur early after allogeneic hematopoietic stem cell transplantation without skin involvement, presenting with rapidly progressive cholestatic liver dysfunction. Early recognition and prompt escalation to multimodal immunosuppressive therapy achieve complete biochemical remission and durable ...
Hind Alhiraki, Amal Ali Fares, Maged Kheder   +2 more
wiley   +1 more source

Epitope-Based Matching for Hla-Alloimmunized Platelet Refractoriness in Patients with Hematologic Diseases

, 2011
BACKGROUND: For HLA-alloimmunized patients, platelet (PLT) concentrations are provided either at matched HLA-A and HLA- B loci or by serologic cross-reactivity groups (CREG) matching strategy However, this method has some limitations STUDY DESIGN AND ...
白舜仲;羅仕錡;林素娟;林東燦;林國信;林亮音, PAI, SHUN-CHUNG;LO, SHYH-CHYI;TSAI, SU-JEN LIN;LIN, DONG-TSAMN;LIN, KUO-SIN;LIN, LIANG-IN   +1 more
core  

Peripartum Anesthetic Management of a Patient With Sickle Cell Disease and Preeclampsia

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Peripartum care for patients with sickle cell disease and preeclampsia requires coordinated multidisciplinary management. Key strategies include multimodal analgesia, individualized transfusion protocols, and vigilant maternal‐fetal monitoring.
Madeline Dow, Aariya Srinivasan, Sabry Ayad   +2 more
wiley   +1 more source

Spontaneous Bilateral Vesical Artery Pseudoaneurysms Presenting With Massive Recurrent Hematuria and Obstructive Acute Kidney Injury: A Case Report

Clinical Case Reports, Volume 14, Issue 10, October 2026.
ABSTRACT Spontaneous development of vesical artery pseudoaneurysm (VA‐PA) as a cause of life‐threatening hematuria is very rare. Most of the existing reports are due to trauma or other types of pelvic surgeries/urological procedures. Incomplete hemostasis in these patients can lead to subsequent complications such as clot retention, severe blood loss ...
Dheeraj Kumar Alias Sailish, Amisha Kumari, Hadia Jamil, Sardar Ravi Singh, Muhammad Hassaan Javaid, Muddassir Khalid, Fred Segawa   +6 more
wiley   +1 more source

Phase 1 dose escalation and expansion trial of the bispecific CD47 inhibitor and CD40 agonist Fc‐fusion protein SL‐172154 (SIRPα‐Fc‐CD40L) in patients with higher‐risk myelodysplastic syndrome or acute myeloid leukemia

Cancer, Volume 132, Issue 19, 1 October 2026.
Abstract Background This clinical trial sought to determine whether SL‐172154 could be combined safely and improve the efficacy of azacitidine (AZA) in patients with higher‐risk myelodysplastic syndrome (HR‐MDS) or acute myeloid leukemia (AML). Methods Dose escalation: doses of 1, 3, and 6 mg/kg SL‐172154 was evaluated as monotherapy or in combination ...
Naval G. Daver, Amer M. Zeidan, Anthony S. Stein, Joshua F. Zeidner, Keri Maher, Emily Curran, Dale Bixby, Wanxing Chai‐Ho, Maximilian Stahl, Karen W. L. Yee, Don Stevens, Sawa Ito, Jana Reynolds, Patrick Medd, Emma Searle, Andrew Sochacki, Mary Lynn Savoie, Steven Green, Kazunobu Kato, Robert Hernandez, Simon Metenou, Bo Ma, Lini Pandite, Taylor H. Schreiber, David A. Sallman   +24 more
wiley   +1 more source

Pyelolithotomy in a patient with Glanzmann thrombasthenia and antiglycoprotein IIb/IIIa antibodies: the shortest possible duration of treatment with recombinant activated factor VII and platelet transfusions

The Turkish Journal of Pediatrics, 2003
Transfusion of platelet concentrates remains the first-line therapy for Glanzmann thrombasthenia in case of bleeding or preparation for surgery. However, development of antibodies to platelet glycoprotein (Gp) IIb/IIIa complex or human leukocyte ...
Omer Devecioğlu, Ayşegül Unüvar, Sema Anak, Ilmay Bilge, Haluk Ander, Orhan Ziylan   +5 more
doaj  

Platelet transfusion refractoriness: how do I diagnose and manage? [PDF]

Hematology Am Soc Hematol Educ Program, 2020
Cohn CS.
europepmc   +1 more source

[Incidence and clinical significance of platelet transfusion refractoriness after allogeneic hematopoietic stem cell transplantation in patients with chronic myelomonocytic leukemia]. [PDF]

Zhonghua Xue Ye Xue Za Zhi, 2022
Zhao C, Zhao XS, Wang Y, Yan CH, Xu LP, Zhang XH, Liu KY, Huang XJ, Sun YQ.   +8 more
europepmc   +1 more source

Clinical Markers of Vulnerability for Bleeding in Men With Prostate Cancer and Antithrombotic Treatment

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Purpose Men with prostate cancer have a high risk for bleeding when treated with antithrombotics. The aim of this study was to investigate clinical markers for vulnerability for bleeding in these men the last year of life. Methods This is a retrospective study on deceased patients with advanced prostate cancer admitted to specialized ...
Linda Björkhem‐Bergman, Christel Hedman, Máté Szilcz, Gabriella Frisk   +3 more
wiley   +1 more source

ATF3 Promotes Solasonine‐Triggered Ferroptosis in Glioma Cells by Suppressing Glycolysis

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Solasonine inhibits glycolysis by increasing ATF3 expression, thereby increasing hydrogen peroxide levels, promoting ferritinophagy and lipid peroxidation, leading to ferroptosis. Furthermore, hydrogen peroxide activates endoplasmic reticulum stress, promoting ATF3 expression, and the whole process forms a positive feedback loop.
Mingbo Jia, Hexin Xiao, Minghao Shi, Yao Li, Yang Yang, Jianing Zhao, Zhuoyue Shan, Pengfei Ge, Liyan Zhao   +8 more
wiley   +1 more source