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Refractoriness to platelet transfusion
Current Opinion in Hematology, 2002This review discusses the causes of refractoriness to platelet transfusions and presents three options for its management. Platelet refractoriness is a complication of platelet transfusion that affects variable proportions of patients, mostly depending on their diagnosis, previous immunologic stimuli, and type of blood products used for transfusion.
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Alloimmune refractoriness to platelet transfusions
Current Opinion in Hematology, 1997Patients who are transfused on multiple occasions with red cells or platelets may develop platelet-reactive alloantibodies and experience decreased clinical responsiveness to platelet transfusion. This situation, conventionally described as "refractoriness to platelet transfusions," is defined by an unsatisfactory low post-transfusion platelet count ...
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The definition of refractoriness to platelet transfusions
Transfusion Medicine, 1992SUMMARY. The relationship between the 1 and 20 h post‐transfusion platelet count and three parameters used to define refractory transfusions, namely the corrected increment (CI), platelet increment (PI), and percentage platelet recovery (%REC), was studied in 437 non‐HLA matched platelet transfusions given to 102 patients with bone marrow failure. The
J F, Bishop +5 more
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Platelet Transfusion Refractory Patients
2009Publisher Summary This chapter focuses on an inappropriately low platelet count defined as platelet refractory, which develops following repeated platelet transfusions. The cause for platelet refractoriness is mentioned to be both non-immune and immune and etiology is often multifactorial.
Jeanne E. Hendrickson, John D. Roback
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Management of Patients Refractory to Platelet Transfusion
Journal of Infusion Nursing, 2007This article discusses the causes and management of platelet refractoriness. Improvements in the quality of platelets and leukoreduction have reduced the morbidity and mortality related to alloimmunization and refractoriness of patients to platelet transfusion.
Porselvi, Chockalingam, Ronald A, Sacher
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Transfusion of ABO‐mismatched platelets leads to early platelet refractoriness
British Journal of Haematology, 1990Summary. Forty‐three consecutive patients previously unexposed to platelets and undergoing treatment for acute leukaemia or autografting for relapsed Hodgkin's lymphoma were randomized to receive transfused platelets of either their own ABO group (OG) or of a major mismatched group (MMG).
R, Carr +4 more
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Refractory Response to Platelet Transfusion Therapy
Journal of Infusion Nursing, 2010Platelet transfusions are commonly used for prophylaxis and treatment of bleeding. After a transfusion, an increment or "boost" is expected to occur. While a number of factors can contribute to a poor posttransfusion increment, refractoriness is typically defined as failure to achieve an appropriate increment after receiving 2 consecutive transfusions ...
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Antileukocyte Antibodies in Patients Refractory to Platelet Transfusions
American Journal of Clinical Pathology, 1979Sera from 12 multitransfused patients who were refractory to random-donor platelets were tested for lymphocytotoxic and leukoagglutinating antibodies using panel cells from various volunteers whose HLA-A and -B antigens were known. All sera contained leukoagglutinins reactive with cells from at least one panel member, whereas only 33% had ...
B R, MacPherson, R G, Westphal
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HLA-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model
Human Gene Therapy, 2013Refractoriness to platelet (PLT) transfusion caused by alloimmunization against HLA class I antigens constitutes a significant clinical problem. Thus, it would be desirable to have PLT units lacking HLA antigens on the cell surface. Previously, we showed that the generation of functional HLA class I-silenced (HLA-universal) PLTs from CD34(+) cells ...
Christiane, Gras +5 more
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Extended platelet transfusion in bleeding patients with platelet transfusion refractoriness
Transfusion and Apheresis Science, 2023Tatiana, Fernández-Barge +6 more
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