Results 291 to 300 of about 643,408 (358)

Activation dynamics study of trapped platelets using a lab-built optical tweezers micro-raman spectrometer. [PDF]

Sci Rep
Mithun N, Shastry S, Mohan G, Lukose J, Matham MV, Chidangil S.   +5 more
europepmc   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Real-time label-free imaging of living crystallization-driven self-assembly. [PDF]

Nat Commun
Guo Y, Xia T, Walter V, Xie Y, Rho JY, Xiao L, O'Reilly RK, Wallace MI.   +7 more
europepmc   +1 more source

MMP9High Neutrophils are Critical Mediators of Neutrophil Extracellular Traps Formation and Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
During a heart attack, neutrophils rapidly activate and differentiate into a specific subset characterized by high levels of MMP9, a tissue‐damaging enzyme, via the SPI1/CST7 pathway. These neutrophils form harmful net‐like structures (Neutrophil extracellular traps, NETs) that exacerbate heart injury.
Shiyu Hu, Feng Zhang, Jingpu Wang, Jian Zhang, Chenguang Li, Yang Lyu, Yiwen Wang, Rong Huang, Yang Gao, Hongbo Yang, Juying Qian, Wenwen Tang, Jiatian Cao, Junbo Ge   +13 more
wiley   +1 more source

Extravascular coagulation regulates haemostasis independently of activated platelet surfaces in an in vivo mouse model. [PDF]

Commun Biol
Sakata A, Tatsumi K, Matsumoto N, Mackman N, Harada S, Kawasaki R, Okuyama-Nishida Y, Soeda T, Nogami K, Shima M.   +9 more
europepmc   +1 more source

Rapid Blood Clot Removal via Remote Delamination and Magnetization of Clot Debris

Advanced Science, EarlyView.
A programmable colloidal microswarm is developed to quickly detach blood clots and enable rapid recanalization, with the detached debris functioning as a magnetic “debris‐robot” that can be efficiently propelled and retrieved via catheter suction, which could significantly save time compared to the critical “Golden 6 hours” window for ischemic stroke ...
Qinglong Wang, Ben Wang, Kai Fung Chan, Xin Song, Qianqian Wang, Fengtong Ji, Lin Su, Bonaventure Yiu Ming Ip, Ho Ko, Philip Wai Yan Chiu, Thomas Wai Hong Leung, Li Zhang   +11 more
wiley   +1 more source

The role of platelets in cancer: from their influence on tumor progression to their potential use in liquid biopsy. [PDF]

Biomark Res
Morales-Pacheco M, Valenzuela-Mayen M, Gonzalez-Alatriste AM, Mendoza-Almanza G, Cortés-Ramírez SA, Losada-García A, Rodríguez-Martínez G, González-Ramírez I, Maldonado-Lagunas V, Vazquez-Santillan K, González-Covarrubias V, Pérez-Plasencia C, Rodríguez-Dorantes M.   +12 more
europepmc   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Beclin 1 of megakaryocytic lineage cells is locally dispensable for platelet hemostasis but functions distally in bone homeostasis. [PDF]

Bone Res
Li L, Zhao C, Zhang R, Wei W, Liu B, Dong J, Gao X, Zhang D, Wang X, Lu M, Zhang Y, Yu Y, Yuan N, Xu Y, Wang J, Fang Y.   +15 more
europepmc   +1 more source