Results 31 to 40 of about 1,117,967 (288)
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP
Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the ...
Wuquan Li, Yan Lv, Yeying Sun
doaj +1 more source
Role of platelets and platelet receptors in cancer metastasis
The interaction of tumor cells with platelets is a prerequisite for successful hematogenous metastatic dissemination. Upon tumor cell arrival in the blood, tumor cells immediately activate platelets to form a permissive microenvironment.
M. Schlesinger
semanticscholar +1 more source
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia
High-altitude polycythemia (HAPC) can occur in individuals who are intolerant to high-altitude hypoxia. In patients with HAPC, erythrocytosis is often accompanied by a decrease in platelet count.
Zhuoya Wang+7 more
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Platelets in wound healing and regenerative medicine
Although platelets are widely recognized as having a critical role in primary hemostasis and thrombosis, increasing experimental and clinical evidence identifies these enucleated cells as relevant modulators of other physiopathological processes ...
J. Etulain
semanticscholar +1 more source
Chronic kidney disease (CKD) is a global health problem and an independent risk factor for cardiovascular morbidity and mortality. Despite evidence-based therapies significantly improving cardiovascular mortality outcomes in the general population and ...
Frances L. Varian+3 more
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Neutrophil extracellular traps (NETs; webs of DNA coated in antimicrobial proteins) are released into the vasculature during sepsis where they contribute to host defense, but also cause tissue damage and organ dysfunction. Various components of NETs have
B. McDonald+6 more
semanticscholar +1 more source
Circulating platelets maintain low cytosolic Ca2+ concentrations. At sites of vascular injury, agonist-induced Ca2+ release from platelet intracellular stores triggers influx of extracellular Ca2+, a process known as store-operated Ca2+ entry (SOCE ...
Robert H. Lee+3 more
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The role of platelets in mediating a response to human influenza infection
Influenza infection increases the incidence of myocardial infarction but the reason is unknown. Platelets mediate vascular occlusion through thrombotic functions but are also recognized to have immunomodulatory activity.
Milka Koupenova+12 more
semanticscholar +1 more source
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy
Many roles of human platelets in health and disease are linked to their ability to transport and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules.
Fred G. Pluthero, Walter H. A. Kahr
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Deep vein thrombosis initiation is mediated by cross talk between monocytes, neutrophils, and platelets.
Marie-Luise von Brühl+31 more
semanticscholar +1 more source