Results 31 to 40 of about 703,101 (336)
Platelets and Anti-platelet Therapy
Journal of Pharmacological Sciences, 2003 Platelets play a central role in the hemostatic process and consequently are similarly involved in the pathological counterpart, thrombosis. They adhere to various subendothelial proteins, exposed either by injury or disease, and subsequently become activated by the thrombogenic surface or locally produced agonists.
Sara J. Israels, Archibald McNicol
openaire +5 more sources
Platelets, 2023 Spleen tyrosine kinase (SYK) is an important regulatory molecule of signal transduction pathways involved in the pathogenesis of autoimmune diseases such as immune thrombocytopenia (ITP), and the SYK-signaling pathway has emerged as a potential target ...
Nichola Cooper +5 more
doaj +1 more source
Platelets, 2022 Bacteremia frequently occurs in patients with acute cholangitis, which could increase the risk of mortality. This single-center retrospective observational study was conducted from July 2013 to July 2020 to evaluate the predictive value of platelet index
XiaoYing Chen +3 more
doaj +1 more source
Effects of exercise on platelet reactivity after myocardial infarction: a randomized clinical trial
Platelets, 2022 Exercise training (ET) can lower platelet reactivity in patients with cardiovascular risk factors. However, the effects of ET on platelet reactivity in higher-risk patients is unknown.
Talia Falcão Dalçóquio +14 more
doaj +1 more source
Roles of non-coding RNA in megakaryocytopoiesis and thrombopoiesis: new target therapies in ITP
Platelets, 2023 Noncoding RNAs (ncRNAs) are a group of RNA molecules that cannot encode proteins, and a better understanding of the complex interaction networks coordinated by ncRNAs will provide a theoretical basis for the development of therapeutics targeting the ...
Wuquan Li, Yan Lv, Yeying Sun
doaj +1 more source
Apoptosis is one cause of thrombocytopenia in patients with high-altitude polycythemia
Platelets, 2023 High-altitude polycythemia (HAPC) can occur in individuals who are intolerant to high-altitude hypoxia. In patients with HAPC, erythrocytosis is often accompanied by a decrease in platelet count.
Zhuoya Wang +7 more
doaj +1 more source
Platelets, 2023 Chronic kidney disease (CKD) is a global health problem and an independent risk factor for cardiovascular morbidity and mortality. Despite evidence-based therapies significantly improving cardiovascular mortality outcomes in the general population and ...
Frances L. Varian +3 more
doaj +1 more source
Platelets, 2023 Circulating platelets maintain low cytosolic Ca2+ concentrations. At sites of vascular injury, agonist-induced Ca2+ release from platelet intracellular stores triggers influx of extracellular Ca2+, a process known as store-operated Ca2+ entry (SOCE ...
Robert H. Lee +3 more
doaj +1 more source
Evaluation of human platelet granules by structured illumination laser fluorescence microscopy
Platelets, 2023 Many roles of human platelets in health and disease are linked to their ability to transport and secrete a variety of small molecules and proteins carried in dense (δ-) and α-granules.
Fred G. Pluthero, Walter H. A. Kahr
doaj +1 more source
The trans-sialidase from Trypanosoma cruzi induces thrombocytopenia during acute Chagas' disease by reducing the platelet sialic acid contents [PDF]
, 2005 Strong thrombocytopenia is observed during acute infection with Trypanosoma cruzi, the parasitic protozoan agent of American trypanosomiasis or Chagas' disease.
Campetella, O. +4 more
core +2 more sources