Results 31 to 40 of about 527,915 (318)

An oligogenic case of severe neonatal thrombocytopenia and a purportedly benign variant in GFI1B requiring reinterpretation

Platelets, 2023
Although thrombocytopenia in neonatal intensive care patients is rarely due to inherited disorders, the number of genetic variants implicated in platelet defects has grown dramatically with increasing genome-wide sequencing.
Max Frenkel, April Hall, M. Stephen Meyn, Carol A. Diamond   +3 more
doaj   +1 more source

Platelet extracellular vesicles are efficient delivery vehicles of doxorubicin, an anti-cancer drug: preparation and in vitro characterization

Platelets, 2023
Platelet extracellular vesicles (PEVs) are an emerging delivery vehi for anticancer drugs due to their ability to target and remain in the tumor microenvironment.
Yu-Wen Wu, Deng-Yao Lee, Yeh-Lin Lu, Liling Delila, Ouada Nebie, Lassina Barro, Chun Austin Changou, Long-Sheng Lu, Hadi Goubran, Thierry Burnouf   +9 more
doaj   +1 more source

Effects of platelet-rich fibrin produced by three centrifugation protocols on bone neoformation in defects created in rat calvaria

Platelets, 2023
This study evaluated the potential of Leukocyte-platelet-rich fibrin (L-PRF; fixed angle centrifugation protocol), Advanced-platelet-rich fibrin (A-PRF; low-speed fixed angle centrifugation protocol), and Horizontal-platelet-rich fibrin (H-PRF ...
Débora de Souza Ferreira Sávio, Lucia Moitrel Pequeno da Silva, Gabriel Guerra David Reis, Ricardo Junior Denardi, Natacha Malu Miranda da Costa, Flávia Aparecida Chaves Furlaneto, Sérgio Luís Scombatti de Souza, Carlos Fernando de Almeida Barros Mourão, Richard J. Miron, Roberta Okamoto, Michel Reis Messora   +10 more
doaj   +1 more source

Neonatal platelet physiology and implications for transfusion

Platelets, 2022
The neonatal hemostatic system is different from that of adults. The differences in levels of procoagulant and anticoagulant factors and the evolving equilibrium in secondary hemostasis during the transition from fetal/neonatal life to infancy, childhood,
Francisca Ferrer-Marín, Martha Sola-Visner   +1 more
doaj   +1 more source

A megakaryocyte with no platelets: Anti-platelet antibodies, apoptosis, and platelet production

Platelets, 2012
Primary immune thrombocytopenia (ITP) and drug-induced thrombocytopenia (DITP) are disorders caused primarily by the presence of anti-platelet auto-antibodies (Abs). Hematologists have traditionally seen thrombocytopenia as the result of increased destruction of Ab-coated platelets by the reticuloendothelial system.
José, Perdomo, Feng, Yan, Beng H, Chong
openaire   +2 more sources

Frozen and cold-stored platelets: reconsidered platelet products

Platelets, 2022
Platelet transfusion, both prophylactic and therapeutic, is a key element in modern medicine. Currently, the standard platelet product for clinical use is platelet concentrates at room temperature (20–24°C) under gentle agitation.
Teresa Jimenez-Marco, Azucena Castrillo, Fernando Hierro-Riu, Vicente Vicente, José Rivera   +4 more
doaj   +1 more source

Platelet-derived respiratory-competent mitochondria transfer to mesenchymal stem cells to promote wound healing via metabolic reprogramming

Platelets, 2022
Mitochondria regulate intracellular metabolism and are also involved in intercellular transfer in vitro and in vivo, thereby affecting the function of adjacent cells.
Enlin Chen, Zhe Chen, Linxi Chen, Xiaoling Hu   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Current challenges in platelet transfusion

Platelets, 2022
The supply of platelets for transfusion is a logistical challenge due to the physiology of platelets and current measures of transfusion performance dictating storage at 22°C and a short product shelf-life (
Peter Smethurst, Rebecca Cardigan
doaj   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source