Results 41 to 50 of about 3,387,841 (331)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Multiplate focusing collimator [PDF]

open access: yes, 1975
An appartus is described for scanning relatively small near sources of penetrating radiation to obtain the energy distribution thereof, wherein a collimator assembly is interposed between a radiation source and a radiation detector.
Hoover, R. B., Underwood, J. H.
core   +1 more source

Fabrication of Electrically Conductive, Fluid Impermeable Direct Methanol Fuel Cell (DMFC) Graphite Bipolar Plates by Indirect Selective Laser Sintering (SLS) [PDF]

open access: yes, 2008
Graphite bipolar plates are highly desirable due to their properties of high electrical conductivity and low weight but are associated with prohibitive machining costs arising from poor mechanical properties.
Alayavalli, Kaushik, Bourell, David L.
core   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

open access: yesFEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino   +7 more
wiley   +1 more source

A new detailed explanation of the Tacoma collapse and some optimization problems to improve the stability of suspension bridges

open access: yesMathematics in Engineering, 2023
We give a new full explanation of the Tacoma Narrows Bridge collapse, occurred on November 7, 1940. Our explanation involves both structural phenomena, such as parametric resonances, and sophisticated mathematical tools, such as the Floquet theory ...
Filippo Gazzola   +2 more
doaj   +1 more source

Ritchey-Chretien Telescope [PDF]

open access: yes, 1973
A Ritchey-Chretien telescope is described which was designed to respond to images located off the optical axis by using two transparent flat plates positioned in the ray path of the image.
Amon, M., Rosin, S.
core   +1 more source

Sound absorption by clamped poroelastic plates [PDF]

open access: yes, 2008
Measurements and predictions have been made of the absorption coefficient and the surface acoustic impedance of poroelastic plates clamped in a large impedance tube and separated from the rigid termination by an air gap.
Attenborough K.   +4 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

open access: yesFEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello   +6 more
wiley   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

open access: yesFEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang   +5 more
wiley   +1 more source

Placas de refratários aluminosos do sistema de válvula gaveta de panelas de aciaria: análise post mortem da degradação química

open access: yesCerâmica
Resumo Em uma aciaria, os recipientes que comportam o aço líquido, tais como o forno e a panela de aciaria, são revestidos com materiais refratários especiais para alta temperatura e elevada resistência ao desgaste.
B. B. de Sousa, S. R. Bragança
doaj   +1 more source

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