Results 51 to 60 of about 450,650 (277)

CGIAR Research Program on Forests, Trees and Agroforestry - Plan of Work and Budget 2020 [PDF]

open access: yes, 2020
There were no significant changes in 2019 to FTA’s theory of change1. FTA plans all its work on the basis of its operational priorities. These, in turn, focusresearch towards major development demands and knowledge gaps, orienting FTA towards the ...
CGIAR Research Program on Forests, Trees and Agroforestry
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Re-engineering the City: Platform Ecosystems and the Capture of Urban Big Data

open access: yesFrontiers in Sustainable Cities, 2020
Today's digital platforms occupy sites of growing strategic significance in the daily lives of cities. Acting as infrastructures of urban exchange, platform services institute basic match-making capabilities between mobile subjects, whether for ...
Sarah Barns
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Networked Platform Governance: The Construction of the Democratic Platform

open access: yesInternational Journal of Communication, 2023
Over the last several years, concerns about the credibility or trustworthiness of information online have been mounting. At the center of these concerns were questions about the role platform companies—particularly search and social media—should play in ...
Robyn Caplan
doaj   +2 more sources

Outside the Black Box

open access: yesWeizenbaum Journal of the Digital Society
Algorithmic transparency is high on the agenda for social media regulation. However, recent work in Science and Technology Studies questions whether this endeavor of “opening the black box” is feasible or even meaningful due to the sociotechnical ...
Paddy Leerssen
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Collaborative governance for the sustainable development goals [PDF]

open access: yes, 2018
The advent of the UN's Sustainable Development Goals has refocused global attention on the roles of business and other nonstate actors in achieving global goals.
Ackerman   +31 more
core   +3 more sources

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Politics of Risk in the Digital Services Act

open access: yesWeizenbaum Journal of the Digital Society
The EU’s 2022 Digital Services Act requires large online platforms to regularly assess and mitigate ‘systemic risks’ to various public-interest goals, including fundamental rights, civic discourse, public health and security.
Rachel Griffin
doaj   +1 more source

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