Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
The Economics of Product-Line Restrictions With an Application to the Network Neutrality Debate [PDF]
We examine the welfare effects of product-line restrictions, such as those called for by some proponents of network neutrality regulation. We consider a platform that brings together households and application providers.
Hermalin, Benjamin E., Katz, Michael
core +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The Public Perception of Hate Speech Regulation in Unconventional Media
Social SciencesThis study provides one of the first quantitative analyses regarding citizens’ perception of hate speech regulation in Spain, based on the influential, empirical study of the Torre Pacheco case.
Ismael Crespo Martínez +2 more
doaj +1 more source
Network Neutrality on the Internet: A Two-sided Market Analysis [PDF]
We discuss the benefits of net neutrality regulation in the context of a two-sided market model in which platforms sell Internet access services to consumers and may set fees to content and applications providers "on the other side" of the Internet. When
Economides, Nicholas, Tåg, Joacim
core
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Innovation and SustainabilityThis article examined the institutional transformations induced by the digital economy, with particular emphasis on their behavioural and strategic implications for economic governance.
H. Bazetska, K. Mykhailova
doaj +1 more source
Net Neutrality on the Internet: A Two-sided Market Analysis [PDF]
We discuss the benefits of net neutrality regulation in the context of a two-sided market model in which platforms sell Internet access services to consumers and may set fees to content and applications providers “on the other side” of the Internet. When
Joacim Tåg, Nicholas Economides
core
Employment and Working Conditions of Selected Types of Platform Work [PDF]
, 2018 Platform work is a form of employment that uses an online platform to match the supply of and demand for paid labour. In Europe, platform work is still small in scale but is rapidly developing.
de Groen, Willem Pieter +3 more
core +1 more source
Characterisation framework of key policy, regulatory and governance dynamics and impacts upon European food value chains: Fairer trading practices, food integrity, and sustainability collaborations. : VALUMICS project “Understanding Food Value Chains and Network Dynamics” funded by EU Horizon 2020 G.A. No 727243. Deliverable D3.3 [PDF]
, 2019 The report provides a framework that categorises the different European Union (EU) policies, laws and governance actions identified as impacting upon food value chains in the defined areas of: fairer trading practices, food integrity (food safety and ...
Barling, David +3 more
core +3 more sources