Results 81 to 90 of about 490,118 (263)

Beyond the Ban: TikTok and the Politics of Digital Sovereignty in the EU and US

open access: yesPolitics and Governance
This article explores the emergence of TikTok as a central issue in contemporary debates on foreign interference, platform regulation, and the governance of transnational data flows.
Fabio Cristiano, Linda Monsees
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Digital Policy as a Driver of Integration: Spillover Effects and European Commission Empowerment

open access: yesPolitics and Governance
The Russian invasion of Ukraine and the global impact of the pandemic brought digital technology to the forefront of geopolitical strategy and geo-economic considerations, prompting European policymakers to embrace strategic autonomy and digital ...
Sebastian Heidebrecht
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

The Regulatory Implications of Subcontracting Practices in Germany’s Location-Based Platforms

open access: yesWeizenbaum Journal of the Digital Society
Subcontracting is becoming a dominant business model in Europe’s platform economy, enabling digital labor platforms to externalize employer responsibilities while retaining control over work through algorithmic management practices.
Didem Özkiziltan Wagenführer   +1 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

open access: yesMolecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla   +4 more
wiley   +1 more source

Platform Practice and Non-Discrimination

open access: yesUniversity of Vienna Law Review
Platforms have developed into important communicative facilities. Rules and practices of platforms define what happens on a platform, but these rules and practices are not free from discrimination.
Felicitas Rachinger
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Regulating Competition in African Digital Markets: From Form to Substance

open access: yesGerman Law Journal
Since the 1980s, many African countries began to adopt competition laws alongside structural adjustment and trade liberalization measures, selectively borrowing from existing EU and U.S. regimes.
Elettra Bietti   +2 more
doaj   +1 more source

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