Results 111 to 120 of about 1,248,661 (307)
Secondary market trading infrastructure of government securities [PDF]
, 2009 The subject of our study is the trading infrastructure of government securities markets, which has undergone fundamental changes driven by the appearance of non-exchange electronic platforms and the rapid rise of their share in the trading volume of ...
Balogh, Csaba, Koczan, Gergely
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Politics of Risk in the Digital Services Act
Weizenbaum Journal of the Digital SocietyThe EU’s 2022 Digital Services Act requires large online platforms to regularly assess and mitigate ‘systemic risks’ to various public-interest goals, including fundamental rights, civic discourse, public health and security.
Rachel Griffin
doaj +1 more source
Solutions for Regulating Labor Relations in the Platform Economy: Iranian Ride-hailing Platform Business [PDF]
مطالعات مدیریت بهبود و تحولThe emergence of Platform Businesses (PBs) has caused a conflict of interest between traditional and new economic players, so, based on the public interest theories to establish justice, the need for government intervention through regulation is ...
Farideh Anvari +3 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Beyond the Ban: TikTok and the Politics of Digital Sovereignty in the EU and US
Politics and GovernanceThis article explores the emergence of TikTok as a central issue in contemporary debates on foreign interference, platform regulation, and the governance of transnational data flows.
Fabio Cristiano, Linda Monsees
doaj +1 more source
Activity regulation for the participative creation of data on-line [PDF]
, 2010 International audienceThis paper discusses automatic regulation in participative Web systems. We present a generic solution with an original trace-centered approach.
Courtin, Christophe +2 more
core +1 more source