Results 121 to 130 of about 1,248,661 (307)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Digital Policy as a Driver of Integration: Spillover Effects and European Commission Empowerment

Politics and Governance
The Russian invasion of Ukraine and the global impact of the pandemic brought digital technology to the forefront of geopolitical strategy and geo-economic considerations, prompting European policymakers to embrace strategic autonomy and digital ...
Sebastian Heidebrecht
doaj   +1 more source

Beyond Bitcoin: Issues in Regulating Blockchain Transactions [PDF]

, 2015
The buzz surrounding Bitcoin has reached a fever pitch. Yet in academic legal discussions, disproportionate emphasis is placed on bitcoins (that is, virtual currency), and little mention is made of blockchain technology—the true innovation behind the ...
Kiviat, Trevor I.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Platform Practice and Non-Discrimination

University of Vienna Law Review
Platforms have developed into important communicative facilities. Rules and practices of platforms define what happens on a platform, but these rules and practices are not free from discrimination.
Felicitas Rachinger
doaj   +1 more source

Two Narratives of Platform Capitalism [PDF]

, 2016
Mainstream economists tend to pride themselves on the discipline\u27s resem­blance to science. But growing concerns about the reproducibility of economic research are undermining that source of legitimacy.
Pasquale, Frank A.
core   +3 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

‘Must-carry’, special treatment and freedom of expression on online platforms: a European story

European Law Open
This paper examines the evolution and implications of ‘must-carry’ obligations in the regulation of online platforms, with a focus on Europe. These obligations, which restrict platforms’ discretion to remove or deprioritise certain content, represent a ...
Aleksandra Kuczerawy, João Pedro Quintais   +1 more
doaj   +1 more source

piRNAs and Aubergine cooperate with Wispy poly(A) polymerase to stabilize mRNAs in the germ plasm

Nature Communications, 2017
In Drosophila embryos, Piwi-interacting RNAs (piRNAs) loaded into the PIWI protein Aubergine target and destabilize maternal mRNAs. Here, the authors provide evidence that piRNAs and Aubergine cooperate with the Wispy poly(A) polymerase to stabilize ...
Jérémy Dufourt, Gwénaëlle Bontonou, Aymeric Chartier, Camille Jahan, Anne-Cécile Meunier, Stéphanie Pierson, Paul F. Harrison, Catherine Papin, Traude H. Beilharz, Martine Simonelig   +9 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source