Results 91 to 100 of about 2,179,474 (280)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Digital Transformation for Smart and Resilient Cities: Assessing Platform Maturity and ISO 37123 Compliance

open access: yesPlatforms
This paper explores the transformative potential of digital platforms in fostering resilient and intelligent urban environments, a critical need considering rapid urbanization and climate change.
Daiane Maria de Genaro Chiroli   +7 more
doaj   +1 more source

Increasing Copyright Protection for Social Media Users by Expanding Social Media Platforms\u27 Rights [PDF]

open access: yes, 2017
Social media platforms allow users to share their creative works with the world. Users take great advantage of this functionality, as Facebook, Instagram, Flickr, Snapchat, and WhatsApp users alone uploaded 1.8 billion photos per day in 2014.
Wichtowski, Ryan
core   +1 more source

Platform Organising and Platform Organisations

open access: yespuntOorg International Journal, 2023
There is a growing consensus that the digital age comes along with the distinguishing organisational form of the platform. Discussions of this organisational form, however, tend to lack a coherent theoretical framing. In this paper, I argue that the distinction between platform organising and platform organisation helps to reduce some of the ...
openaire   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Industry 4.0 and Sustainability: Empirical Validation of Constructs of Industry Technology and Sustainable Development

open access: yesPlatforms
The study has as purpose to identify, analyze, and validate challenge constructs of Industry 4.0, which can affect the promotion of sustainability within the industry.
Lucas da Silva Melo   +6 more
doaj   +1 more source

eIF2α phosphorylation: A hallmark of immunogenic cell death

open access: yesOncoImmunology, 2018
Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely
Lucillia Bezu   +5 more
doaj   +1 more source

Ventures in Social Media [PDF]

open access: yes, 2014
Academic libraries are actively involved in social media platforms as part of their campus communities. They have moved past the debate of whether to participate in social media and are focusing on strategies to develop engaging content and assessment of
Burgert, Lisa   +2 more
core  

Detecting Sarcasm in Multimodal Social Platforms

open access: yes, 2016
Sarcasm is a peculiar form of sentiment expression, where the surface sentiment differs from the implied sentiment. The detection of sarcasm in social media platforms has been applied in the past mainly to textual utterances where lexical indicators ...
Bamman D.   +14 more
core   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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