Results 91 to 100 of about 2,214,681 (281)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Green Taxation, Urban Investment Platform Debt, and Urban Green Transformation

Platforms
Green development serves as the foundation for high-quality development. As one of the most commonly used macroeconomic regulation policies, taxation is a crucial component of the modernization of the national governance system and governance capacity ...
Haiyang Zhou, Yonghao Guan, Shiyu Huang, Enhui Zhao, Han Xu   +4 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Digital Intermediation and Precarity: Experiences of Domestic Workers in Chile’s Platform Labor Economy

Platforms
This article explores the implications of digital labor intermediation platforms in paid domestic work (PDW) in Chile, a sector historically marked by informality and vulnerability.
Rosa Villarroel-Valdés, Carla Valdés-Sarmiento, Nelson Lay-Raby   +2 more
doaj   +1 more source

Detecting Sarcasm in Multimodal Social Platforms

, 2016
Sarcasm is a peculiar form of sentiment expression, where the surface sentiment differs from the implied sentiment. The detection of sarcasm in social media platforms has been applied in the past mainly to textual utterances where lexical indicators ...
Bamman D., Davidov D., Frome A., Ghosh D., Gibbs R., González-Ibánez R., Kincaid J. P., Mikolov T., Riloff E., Tepperman J., Tsur O., Veale T., Verstraten P., Wang Z., You Q.   +14 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Driving Strategic Innovation Through AI Adoption in Government Financial Regulators: A Case Study

Platforms
Public institutions are experiencing increased dynamism due to rapid technological development and digitalization, which are creating novel opportunities for innovation.
Carlos Andrés Merlano Porras, Luis Arregoces Castillo, Lisa Bosman, Monica Gamez-Djokic   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The Social Responsibility of Young Professionals Working with Information Systems and Technologies

Platforms
Research purpose—Economy digital transformation has had a strong impact on several areas, such as employment, economic organization modus operandi, or the digital modernization of economic agents.
Pedro Anunciação, Filipe Lemos, Mónica Bumba   +2 more
doaj   +1 more source

Ventures in Social Media [PDF]

, 2014
Academic libraries are actively involved in social media platforms as part of their campus communities. They have moved past the debate of whether to participate in social media and are focusing on strategies to develop engaging content and assessment of
Burgert, Lisa, Nann, Alejandra, Sterling, Lorelei   +2 more
core