Results 71 to 80 of about 3,596,701 (267)

Jacques Henriot et les sciences du jeu ou la pensée de Villetaneuse

Sciences du Jeu, 2013
This introductive chapter looks back on Jacques Henriot’s conception of play, from his first phenomenological approach grounded in his philosophical work about obligation, to the approach centred on the idea of play, questioning the uses of the word in ...
Gilles Brougère
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Play qualities: Playful actions in learning processes in teacher education and social education

Social Sciences and Humanities Open
In this paper, we investigate the concept of play qualities with the aim of supporting, creating, analysing, and evaluating playful approaches to learning in teacher education and social education.
Helle Hovgaard Jørgensen, Helle Marie Skovbjerg   +1 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

2025 Position statement on active outdoor play

International Journal of Behavioral Nutrition and Physical Activity
Background In 2015, the Position Statement on Active Outdoor Play was released in Canada, emphasizing the critical role of active outdoor play—with its risks—in fostering children’s healthy development.
Eun-Young Lee, Louise de Lannoy, Yeong-Bae Kim, Apoorva Rathod, Maeghan E. James, Olivia Lopes, Brianna Nasrallah, Anujah Thankarajah, Dina Adjei-Boadi, Maria Isabel Amando de Barros, Scott Duncan, Robyn Monro Miller, Lærke Mygind, Leigh M. Vanderloo, Po-Yu Wang, Mark S. Tremblay, AOP10 Steering Committee Group   +16 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The relationship of adults’ memories of their childhood play with their children’s life satisfaction and attitude to the game of their children

Современное дошкольное образование
Background. The value of the children’s game lies in its developing potential, which determines the need to support it by adults, especially parents. Research indicates that such support contributes to better developmental outcomes in children. Moreover,
Irina A. Ryabkova, Victoria M. Chernaya, Irina A. Kan   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source