Free water in white matter links focal hemodynamic compromise to cognitive impairment in asymptomatic extracranial carotid artery stenosis. [PDF]
BMC Med ImagingShao S +5 more
europepmc +1 more source
Global Policy, EarlyView.ABSTRACT This article explores the current controversies surrounding the European Ariane launcher and its implications for the future of European space governance. The Ariane program, historically a symbol of European technopolitical integration, faces mounting challenges due to delays, rising costs and increasing competition from private actors like ...
Nina Klimburg‐Witjes, Joseph Popper
wiley +1 more source
First Evidences of the Point-Light Display Observation Methodology in Multi-Pathology Care: A Retrospective Analysis. [PDF]
Health Sci RepFrancisco V +5 more
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Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Covalent fluorescent probes for 2‐arachidonoylglycerol metabolic pathways
British Journal of Pharmacology, EarlyView.Abstract Covalent fluorescent probes have emerged as versatile chemical tools to visualise active enzymes in complex biological systems. When tailored for specific applications, ranging from activity‐based protein profiling for drug development to high spatiotemporal resolution imaging of enzymatic activities, these probes provide unique insights into ...
Nick D. F. Puijmbroeck +1 more
wiley +1 more source
Primary hepatic diffuse large B-cell lymphoma in a patient with polycystic liver disease: a case report and literature review. [PDF]
Front OncolDing JS, Zhang M, Zhou F.
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The FEBS Journal, EarlyView.Pyridoxal 5′‐phosphate (PLP) homeostasis relies on salvage enzymes, yet key metabolic branches remain undefined. We identify AKR1C isozymes as previously undescribed contributors that convert pyridoxal into pyridoxine or 4‐pyridoxolactone through reductase and dehydrogenase activities.
Nayu Kito +8 more
wiley +1 more source
Polydatin Protects Against the Formation of PPE-Induced Abdominal Aortic Aneurysms in Mice by Activating Nuclear Factor Erythroid 2-Related Factor 2. [PDF]
Drug Dev ResLiu Z, Zhu J, Zhou Q, Qian H, Cui F.
europepmc +1 more source
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +1 more source
Analysis of Respiratory Microbiota Characteristics in Patients with COPD and High-Risk Populations Using 16S rRNA Technology. [PDF]
Int J Chron Obstruct Pulmon DisYu Y +6 more
europepmc +1 more source