Results 71 to 80 of about 31,406 (294)

Phospholipase D functional ablation has a protective effect in an Alzheimer’s disease Caenorhabditis elegans model

Scientific Reports, 2018
Phospholipase D (PLD) is a key player in the modulation of multiple aspects of cell physiology and has been proposed as a therapeutic target for Alzheimer’s disease (AD).
Francisca Vaz Bravo, Jorge Da Silva, Robin Barry Chan, Gilbert Di Paolo, Andreia Teixeira-Castro, Tiago Gil Oliveira   +5 more
doaj   +1 more source

PLD and mTOR pathway in PKD.

, 2013
(A) Elevated PLD activity stimulates the mTORC1, mTORC2 and other relative pathways and promotes cell proliferation in PKD cells. (B) Inhibition of PLD reduces phosphorylation of downstream targets of mTORC1 and mTORC2, and induces autophagy in PKD cells.
Urs Ziegler (6850), Andres Käch (449817), Yang Liu (4829), Albert C. M. Ong (449818), Alexandre Arcaro (68424), Darren P. Wallace (160449), Andreas L. Serra (103592)   +6 more
core   +1 more source

Epitaxial Bi2O2Se/Bi2O5Se Thin Films: Revealing Electric‐Field‐Driven Oxidation and Resistive Switching Dynamics for Advanced Memory Devices

Advanced Science, EarlyView.
Bi2O2Se/Bi2O5Se bilayer heterostructure exhibits reversible structural evolution during device operation, directly revealed by atomic‐scale investigation. Oxygen vacancy redistribution governs filament formation and rupture, enabling stable multilevel resistive switching and synaptic‐like behaviors.
Yen‐Jung Chen, Yong‐Jyun Wang, Zi‐Qin Hong, Chien‐Hua Wang, Yi‐Ning Wang, Jia De Cheng, Chun‐Wei Huang, Ying‐Hao Chu, Wen‐Wei Wu   +8 more
wiley   +1 more source

Double-beam-PLD for metals

, 2022
S.861Pulsed Laser ablation is a very promising method for producing beams of highly excited particles suited for high quality deposition (Pulsed Laser Deposition PLD).
Völlmar, S., Granze, G., Schultrich, B., Lenk, A.   +3 more
core  

Large‐Scale Growth of Self‐Poled Ferroelectric Rashba Semiconductor α‐GeTe(111) Thin Films: A Crucial Step Towards Future CMOS‐Compatible Ferroelectric Spintronic Devices

Advanced Science, EarlyView.
Ferroelectric Rashba semiconductors promise ultralow‐power devices but lack industry‐quality films. This work demonstrates CMOS‐compatible fabrication of high‐quality α‐GeTe(111) films via magnetron sputtering, enabled by a 5 nm Sb2Te3 seed layer. Structural and ferroelectric analyses show robust, switchable polarization comparable to MBE films, paving
Jules Lagrave, Nicolas Bernier, Thomas Jalabert, Yoann Brûlé, Damien Térébénec, Pierre Meilleur, Hervé Roussel, Jean‐Baptiste Dory, Oussama J. Mouawad, Thibault Chommaux, Cristian Mocuta, Dominique Thiaudière, Laurent Vila, Françoise Hippert, Pierre Noé   +14 more
wiley   +1 more source

Therapeutic Apheresis, Circulating PLD, and Mucocutaneous Toxicity: Our Clinical Experience through Four Years

Pharmaceutics, 2020
Cancer treatment has been greatly improved by the combined use of targeted therapies and novel biotechnological methods. Regarding the former, pegylated liposomal doxorubicin (PLD) has a preferential accumulation within cancer tumors, thus having lower ...
Stanislav Filip, Ondřej Kubeček, Jiří Špaček, Miriam Lánská, Milan Bláha   +4 more
doaj   +1 more source

Elective liver transplantation (PLD vs Non-PLD) by centre.

Elective liver transplantation (PLD vs Non-PLD) by centre.
Matt Gittus (17720545), Albert C. M. Ong (9711541), Joanna Moore (16235024)   +2 more
core   +1 more source

GPI-specific phospholipase D (GPI-PLD) is expressed during mouse development and is localized to the extracellular matrix of the developing mouse skeleton

, 2005
Glycosylphosphatidylinositol-specific phospholipase D (GPI-PLD) is abundant in serum and has a well-characterized biochemistry; however, its physiological role is completely unknown.
Zürcher, Gisela, Rohrbach, Valeria, Brodbeck, Urs, Bütikofer, Peter, Andres, Anne-Catherine, Gregory, Patrick, Gentinetta, René, Kraemer, Elisabeth, Ziemiecki, Andrew   +8 more
core   +1 more source

Upfront Taxane Could Be Superior to Pegylated Liposomal Doxorubicin (PLD): A Retrospective Real-World Analysis of Treatment Sequence Taxane–PLD versus PLD–Taxane in Patients with Metastatic Breast Cancer

, 2023
Background: Patients with endocrine-resistant metastatic breast cancer (MBC) require cytostatic therapy. Single-agent taxanes and anthracyclines, including pegylated liposomal doxorubicin (PLD), are standard treatment options.
Vetter, Marcus, Rochlitz, Christoph, Wallrabenstein, Till, Christoph Rochlitz, Daetwyler, Eveline, Till Wallrabenstein, Marcus Vetter, Eveline Daetwyler, Oseledchyk, Anton, Anton Oseledchyk   +9 more
core   +1 more source

Targeting PLD3 Reverses the Immunosuppressive Niche by Reprogramming Tumor‐Associated Macrophages and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
PLD3 activates the lysosomal‐AKT‐NF‐κB axis to drive cellular senescence in macrophages, establishing an immunosuppressive TME by limiting the infiltration of cytotoxic T, NK, and NKT cells, which confers resistance to anti‐PD‐1 therapy. Abrine inhibits PLD3 expression, restoring antitumor immunity and synergizing with anti‐PD‐1 treatment.
Xingtu Qin, Qiong Li, Xuemei Xu, Yuhan Wu, Yin Zhu, Jieqiong Wu, Yuan Fang, Qiubei Chen, Shuyang Wang, Jiang Yu, Yaping Ye, Hongli Jiao   +11 more
wiley   +1 more source