Results 61 to 70 of about 146,708 (349)

Pleural fluid cell-free DNA integrity index to identify cytologically negative malignant pleural effusions including mesotheliomas

BMC Cancer, 2012
Background The diagnosis of malignant pleural effusions (MPE) is often clinically challenging, especially if the cytology is negative for malignancy. DNA integrity index has been reported to be a marker of malignancy.
Sriram Krishna B, Relan Vandana, Clarke Belinda E, Duhig Edwina E, Windsor Morgan N, Matar Kevin S, Naidoo Rishendran, Passmore Linda, McCaul Elizabeth, Courtney Deborah, Yang Ian A, Bowman Rayleen V, Fong Kwun M   +12 more
doaj   +1 more source

Positive pressure–assisted pleural aspiration: A case report of a novel procedure and a review of literature

SAGE Open Medical Case Reports, 2022
Drainage of a pleural effusion is done either by inserting an intercostal tube or by aspirating pleural fluid using a syringe. The latter is a time-consuming and labour-intensive procedure.
Pramith Shashinda Ruwanpathirana, Ravini Karunatillake, Saroj Jayasinghe   +2 more
doaj   +1 more source

Survival prediction in mesothelioma using a scalable lasso regression model: instructions for use and initial performance using clinical predictors [PDF]

, 2018
Introduction: Accurate prognostication is difficult in malignant pleural mesothelioma (MPM). We developed a set of robust computational models to quantify the prognostic value of routinely available clinical data, which form the basis of published MPM ...
Blyth, Kevin G., Bylesjo, Max, Halligan, Daniel L., Kidd, Andrew C., McGettrick, Michael, Tsim, Selina   +5 more
core   +1 more source

Correlation between pleural fluid cytology and magnitude of pleural invasion in patients with malignant pleural mesothelioma

The Egyptian Journal of Bronchology, 2016
Introduction Malignant pleural mesothelioma (MPM) is an aggressive tumor commonly triggered by exposure to asbestos, and commonly presented with unilateral pleural effusion.
Amr M. Shoukri, Nermine M. Riad
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

C-reactive protein and serum amyloid A levels in discriminating malignant from non-malignant pleural effusion

Egyptian Journal of Chest Disease and Tuberculosis, 2015
Introduction: Distinction between malignant and non-malignant pleural effusion is of great importance in the patient management. The aim: We examined the diagnostic value of C-reactive protein (CRP) and serum amyloid A (SAA) in distinguishing different ...
Hala Mohamed Shalaby Samaha, Amany Ragab Elsaid, Rasha Elzehery, Rania Elhelaly   +3 more
doaj   +1 more source

Characteristics of pleural effusion with a high adenosine deaminase level: a case–control study

BMC Pulmonary Medicine, 2022
Background Increased pleural fluid adenosine deaminase (ADA) is useful for diagnosing tuberculous pleurisy (TB), but high ADA levels are associated with other diseases.
Masafumi Shimoda, Aya Hirata, Yoshiaki Tanaka, Kozo Morimoto, Takashi Yoshiyama, Kozo Yoshimori, Takeshi Saraya, Haruyuki Ishii, Ken Ohta   +8 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source