Results 171 to 180 of about 7,658 (197)
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Immunologic Research, 2008
Semaphorin and plexin proteins were originally identified for their important axon guidance regulation. In recent years, their role within the immune system has been discovered. Semaphorins are considered the ligands to the plexin receptors, and together, they mediate cell-cell communication.
Brian P, O'Connor, Jenny P-Y, Ting
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Semaphorin and plexin proteins were originally identified for their important axon guidance regulation. In recent years, their role within the immune system has been discovered. Semaphorins are considered the ligands to the plexin receptors, and together, they mediate cell-cell communication.
Brian P, O'Connor, Jenny P-Y, Ting
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The Function of Neuropilin/Plexin Complexes
2002Neuropilins bind the secreted class 3 semaphorins with high affinity but require a member of the plexin family to form receptors that are able to activate downstream signal transduction cascades. In this receptor complex neuropilins act as the ligand-binding subunit while plexins function as the signal-transducing subunit in the induction of ...
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Domains in plexins: links to integrins and transcription factors
Trends in Biochemical Sciences, 1999P. B., B. S. and T. D. are supported by the EU and the DFG; T. A. S. is supported by the NIH.
Bork, Peer +3 more
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More than nervous: The emerging roles of plexins
Differentiation, 2012Plexins are the receptors for semaphorins, a large family of axon guidance cues. Accordingly, the role of plexins in the development of the nervous system was the first to be acknowledged. However, the expression of plexins is not restricted to neuronal cells, and recent research has been increasingly focused on the roles of plexin-semaphorin ...
Nina, Perälä +2 more
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Repulsive Plexin Signaling Mediators
Science Signaling, 2001Semaphorins mediate axon repulsion through interactions with their receptors the Plexins. Two papers now identify some of the signaling elements in axon guidance that are mediated by Plexin A and Plexin B: Hu et al. investigated signaling from Plexin B to two cytoskeletal regulators, the Rac and Rho guanosine ...
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Plexin-A4 mediates amyloid-β–induced tau pathology in Alzheimer’s disease animal model
Progress in Neurobiology, 2021Sunwoo Chung +2 more
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Semaphorin-Plexin Signaling: From Axonal Guidance to a New X-Linked Intellectual Disability Syndrome
Pediatric Neurology, 2022Ebba Alkhunaizi +2 more
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