Pharmaceutically modified subtilisins withstand acidic conditions and effectively degrade gluten in vivo [PDF]
, 2019 Detoxification of gluten immunogenic epitopes is a promising strategy for the treatment of celiac disease. Our previous studies have shown that these epitopes can be degraded in vitro by subtilisin enzymes derived from Rothia mucilaginosa, a natural ...
Darwish, Ghassan +4 more
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Evaluation of poly (lactic-co-glycolic acid) nanoparticles to improve the therapeutic efficacy of paclitaxel in breast cancer [PDF]
BioImpacts, 2022 Introduction: Paclitaxel (PTX) is a cornerstone in the treatment of breast cancer, the most common type of cancer in women. However, this drug has serious limitations, including lack of tissue-specificity, poor water solubility, and the development of ...
Laura Cabeza +9 more
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Targeted protein delivery: carbodiimide crosslinking influences protein release from microparticles incorporated within collagen scaffolds [PDF]
, 2019 open access articleTissue engineering response may be tailored via controlled, sustained release of active agents from protein-loaded degradable microparticles incorporated directly within three-dimensional (3D) ice-templated collagen scaffolds. However,
Best, S. +6 more
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Comparing the immune response to a novel intranasal nanoparticle PLGA vaccine and a commercial BPI3V vaccine in dairy calves [PDF]
, 2015 peer-reviewedBackground There is a need to improve vaccination against respiratory pathogens in calves by stimulation of local immunity at the site of pathogen entry at an early stage in life. Ideally such a vaccine preparation would not be inhibited by
A Menanteau-Horta +42 more
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Drug Design, Development and Therapy, 2021 Yang Sun, Di Long Department of Orthopaedics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, People’s Republic of ChinaCorrespondence: Yang Sun Email sunyang797979@163.comBackground: The present work is an effort to develop a ...
Sun Y, Long D
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Nanoparticle drug delivery systems for inner ear therapy: An overview [PDF]
, 2017 open7noembargoed_20180701Valente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini, AlessandroValente, Filippo; Astolfi, Laura; Simoni, Edi; Danti, Serena; Franceschini, Valeria; Chicca, Milvia; Martini,
Astolfi, Laura +6 more
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Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer [PDF]
Artificial Cells, Nanomedicine, and Biotechnology, 2018 Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC).
Parisa, Nasrollahi +5 more
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Vaccines, 2019 Formulation of inhalable delivery systems containing tuberculosis (TB) antigens to target the site of infection (lungs) have been considered for the development of subunit vaccines. Inert delivery systems such as poly (lactic-co-glycolic acid) (PLGA) are
Carla B. Roces +4 more
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Cytotoxic and mutagenic potential of juglone: a comparison of free and nano-encapsulated form
Arhiv za Higijenu Rada i Toksikologiju, 2020 Despite its evidenced beneficial herbicidal, antibacterial, antiviral, antifungal, and antioxidant effects, the application of juglone (5-hydroxy-1,4,-naphthoquinone) is limited due to its low water solubility and allelopathic and toxic effects.
Erisen Semiha +4 more
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Immunization against Pseudomonas aeruginosa using Alg-PLGA nano-vaccine [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Pseudomonas aeruginosa is the bacterium that causes of pulmonary infection among chronically hospitalized patients. Alginate is a common surface antigen of P.
Saeid Azimi, Leila Safari Zanjani
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