Results 51 to 60 of about 44,745 (266)

Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

Design and Optimization of Sustained-Release Dental Implants for Targeted Periodontal Drug Delivery

Journal of Pharmacy and Bioallied Sciences
Background: Periodontal therapy often requires sustained and targeted drug delivery to enhance therapeutic outcomes and minimize systemic side effects.
Silpi Chatterjee, Daya Shankar, Yagyesh Mehta, Swamini Ajay Shete, Asim Mustafa Khan, Ankita Kumari   +5 more
doaj   +1 more source

Exploring the immunopotentiation of Chinese yam polysaccharide poly(lactic-co-glycolic acid) nanoparticles in an ovalbumin vaccine formulation in vivo

Drug Delivery, 2017
Biocompatible and biodegradable poly(lactic-co-glycolic acid) (PLGA) has been approved by the US Food and Drug Administration and has frequently been used to develop potential vaccine delivery systems.
Li Luo, Tao Qin, Yifan Huang, Sisi Zheng, Ruonan Bo, Zhenguang Liu, Jie Xing, Yuanliang Hu, Jiaguo Liu, Deyun Wang   +9 more
doaj   +1 more source

CircFAM65A/CANX Condensates Sequester FAM134B to Inhibit ER-phagy and Suppress Hepatocellular Carcinoma Progression. [PDF]

Adv Sci (Weinh)
The novel circRNA circFAM65A suppresses HCC progression. Mechanistically, circFAM65A drives CANX phase separation, which recruits FAM134B into condensates and blocks its interaction with LC3, thereby inhibiting ER‐phagy and HCC progression. Importantly, targeted circFAM65A delivery represents a potential therapeutic strategy for HCC.
Ru W, Gan L, Lu Y, Guo Y, Huang Q, Yin S, Nie F, Di S, Ning J, Yao S, Wan H, Liu L, Liu Z, Yang F, Qin W, Wen W.   +15 more
europepmc   +2 more sources

Sustained release of sodium deoxycholate from PLGA–PEG–PLGA thermosensitive polymer [PDF]

Artificial Cells, Nanomedicine, and Biotechnology, 2018
Delivery of the drugs to the target tissue and reducing their side effects on surrounding tissues is still a significant challenge for pharmaceutical scientists. The aim of this study was to investigate the suitability of PLGA–PEG–PLGA triblock copolymer as a matrix material for a sustained-release system of sodium deoxycholate (NaDC).
Parisa, Nasrollahi, Khosro, Khajeh, Elnaz, Tamjid, Mohammad, Taleb, Masoud, Soleimani, Guangjun, Nie   +5 more
openaire   +2 more sources

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Cell‐Based Biohybrid Micro/Nanorobots for Biotherapy

Advanced Robotics Research, EarlyView.
This review systematically evaluates cell‐based biohybrid micro/nanorobots (CB‐BMRs), highlighting their cell selection criteria, fabrication strategies, and diverse actuation modes. Furthermore, it surveys the promising therapeutic applications of CB‐BMRs in targeted cancer, thrombosis, and inflammation treatments, while comprehensively discussing ...
Lin Wang, Chenlu Liu, Yu Zhao, Chuanhua Li, Xuyang Chen, Shixiao Ding, Lizhou Dai, Guokun Wang, Tianlong Li, Jiaxin Li, Xuejia Liu, Haocheng Wang   +11 more
wiley   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Understanding of Protein Adhesion to PLGA Through Molecular Docking Analysis

Cumhuriyet Science Journal
In tissue engineering, cellular adhesion is a multistep process which occurs between the cell and the specific molecules and proteins that are adsorbed from biological fluids to the material surface.
Sema Zabcı, Didem Mimiroğlu
doaj   +1 more source

PLGA‐PEG‐PLGA Polymer: From Synthesis to Advanced Pharmaceutical Applications

Advances in Polymer Technology
This paper presents an in‐depth analysis of the PLGA‐PEG‐PLGA polymer, focusing on its synthesis and applications in advanced drug delivery systems (DDSs). PLGA‐PEG‐PLGA, a triblock copolymer, gains attention due to its biodegradability, biocompatibility, and thermosensitive properties, making it suitable for encapsulating both ...
Bartosz Strus, Arkadiusz Szterk
openaire   +2 more sources