Results 61 to 70 of about 90,317 (313)

Strategies for Loading and Releasing Peptide Therapeutics in Biodegradable Carriers

Advanced Functional Materials, EarlyView.
A biodegradable carrier‐based peptide delivery system is a powerful treatment platform for diverse diseases, owing to its superior therapeutic efficacy and low toxicity. This review examines the conventional peptide‐loaded carrier fabrication process and its current limitations.
Wookyoung Jang, Ki Wan Bong
wiley   +1 more source

Protein-loaded PLGA–PEG–PLGA microspheres: A tool for cell therapy

European Journal of Pharmaceutical Sciences, 2012
A promising strategy to repair injured organs is possible by delivering a growth factor via poly-(d,l lactide-co-glycolide) (PLGA) microspheres; the latter are coated with adhesion molecules that serve as a support for cell delivery. At present, PLGA is not the optimal choice of polymer because of poor or incomplete protein release.
Van-Thanh, Tran, Jean-Pierre, Karam, Xavier, Garric, Jean, Coudane, Jean-Pierre, Benoît, Claudia N, Montero-Menei, Marie-Claire, Venier-Julienne   +6 more
openaire   +2 more sources

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

The Antimicrobial Effects of Poly(Lactic-Co-Glycolic Acid)/Xylitol Nanoparticles on Microorganisms Causing Dental Caries (In Vitro Study)

Medical Journal of Babylon
Background: Many people all around the world suffer from tooth decay, a chronic infectious disease that can lead to tooth loss. Streptococcus mutans and Candida albicans are typical microorganisms involved in the caries process.
Ghada Abdul Salam Ibrahim, Eaman Ali AL-Rubaee, Maha Jamal Abbas   +2 more
doaj   +1 more source

The improved antitumor efficacy of continuous intratumoral chemotherapy with cisplatin-loaded implants for the treatment of sarcoma 180 tumor-bearing mice

Drug Delivery, 2019
Cisplatin is the most commonly used antitumor drug in the chemotherapy of a variety of malignancies. However, the severe side effects and drug resistance limit its clinical application.
Li Gao, Shang Cai, Awei Cai, Yang Zhao, Tangbing Xu, Yan Ma, Yan Xu, Yuan Wang, Hao Wang, Yong Hu   +9 more
doaj   +1 more source

Development of PLGA-coated β-TCP scaffolds containing VEGF for bone tissue engineering [PDF]

, 2016
Bone tissue engineering is sought to apply strategies for bone defects healing without limitations and short-comings of using either bone autografts or allografts and xenografts. The aim of this study was to fabricate a thin layer poly(lactic-co-glycolic)
Bastami, Farshid, Eslaminejad, Mohamadreza Baghaban, Fahimipour, Farahnaz, Jafarian, Mohammad, Jahangir, Shahrbanoo, Karkhaneh, Akbar, Khojasteh, Arash, Tahriri, Mohammadreza, Tayebi, Lobat   +8 more
core   +1 more source

ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids [PDF]

, 2020
CD1d-restricted invariant natural killer T (iNKT) cells constitute a common glycolipid-reactive innate-like T-cell subset with a broad impact on innate and adaptive immunity.
Cheng, Tan‐Yun, Cloots, Eva, De Geest, Bruno, Drennan, Michael, Elewaut, Dirk, Gaublomme, Djoere, Govindarajan, Srinath, Gysens, Fien, Janssens, Sophie, Maelegheer, Margaux, Moody, D Branch, Venken, Koen, Verheugen, Eveline   +12 more
core   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Thymoquinone-PLGA-PVA Nanoparticles Ameliorate Bleomycin-Induced Pulmonary Fibrosis in Rats via Regulation of Inflammatory Cytokines and iNOS Signaling

Animals, 2019
Pulmonary fibrosis is considered one of the most chronic interstitial illnesses which are not easily treated. thymoquinone’s (TQ) benefits are still partly problematic due to poor water solubility; therefore, it was loaded onto PLGA-PVA carriers ...
Sultan A. M. Saghir, Naif A. Al-Gabri, Asmaa F. Khafaga, Nahla H. El-shaer, Khaled A. Alhumaidh, Mohamed F. Elsadek, Badreldin M. Ahmed, Daniyah M. Alkhawtani, Mohamed E. Abd El-Hack   +8 more
doaj   +1 more source

PRP and BMAC for Musculoskeletal Conditions via Biomaterial Carriers. [PDF]

, 2019
Platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC) are orthobiologic therapies considered as an alternative to the current therapies for muscle, bone and cartilage. Different formulations of biomaterials have been used as carriers for
Shams, Shahin, Silva, Eduardo A, Stilhano, Roberta S, Yamaguchi, Fabio SM   +3 more
core   +1 more source