Results 151 to 160 of about 37,977 (250)

Historical Plant Embryos as Alternative Sources of Ancient DNA for Whole Genome Sequencing

open access: yesMolecular Ecology Resources, Volume 26, Issue 7, October 2026.
ABSTRACT Natural history and agricultural collections contain hundreds of millions of specimens classified in terms of time, space and taxonomy. Since the first success of ancient DNA (aDNA) isolation in the 1980s, these repositories, including herbaria for plants, have been intensively used to support studies in taxonomy, macroevolution and genetic ...
Hong Phuong Le   +7 more
wiley   +1 more source

Dietary CoQ10 Ameliorates Age‐Related Megakaryocyte Dysfunction via COPS3‐Mediated Activation of Autophagy

open access: yesAging Cell, Volume 25, Issue 10, October 2026.
Dietary CoQ10 improves megakaryocyte maturation and polyploidization and reduces platelet hyperreactivity in naturally aged mice, while experiments in senescent Meg‐01 cells demonstrate enhanced autophagic flux and identify COPS3 as a contributing, but not, mediator.
Yixuan Xu   +9 more
wiley   +1 more source

A Three‐Dimensional Culture–Drug Sensitivity Test Predicts MDM2 Inhibitor–Sensitivity in SMARCB1/INI1‐Deficient Tumors

open access: yesCancer Science, Volume 117, Issue 10, Page 2852-2862, October 2026.
This study aimed to determine whether personalized selection of effective drugs for SMARCB1/INI1‐deficient tumors is feasible using in vitro drug sensitivity profiling. Drug sensitivity was assessed using a short‐term collagen gel–embedded three‐dimensional drug sensitivity test (3D‐DST) in tumors derived from SMARCB1/INI1‐deficient tumor cell line ...
Hiroaki Goto   +12 more
wiley   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

open access: yesEuropean Journal of Haematology, Volume 117, Issue 4, Page 728-738, October 2026.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco   +2 more
wiley   +1 more source

Assessing Future Maladaptation Risk in the Keystone Species Populus tremuloides

open access: yesEvolutionary Applications, Volume 19, Issue 10, October 2026.
ABSTRACT Understanding the adaptive potential of widespread trees is critical for predicting species resilience under climate change and informing their conservation strategies. We assessed the genomic offset in Populus tremuloides Michx. (aspen) using 10,937 genotyping‐by‐sequencing derived, high‐quality SNPs from 891 individuals sampled across the ...
Melanie Zacharias   +8 more
wiley   +1 more source

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