Results 71 to 80 of about 1,522,201 (266)

Drama and satiric prose by Lutfali Hasanov

Studia Humanitatis, 2023
The article studies drama and prose by Lutfali Hasanov who wrote and created works in Sheki literary atmosphere during the 40-70s of the 20th century and led the literary council of “Sabuhi” for a long time. The ideological relevance of the plays such as
Adishirinov Kamil Fikrat
doaj  

Phalerae from the Mound Sadovy and the Image of the ‘Tarandrus’

Вестник Волгоградского государственного университета. Серия 4. История, регионоведение, международные отношения, 2018
This paper is devoted to the content of the composition on the phalerae from the mound Sadovy and to the related issue about the existence of the ‘tarandrus’ image in the art of Eurasian nomads. L. S.
Irina P. Zasetskaya
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

СЮЖЕТНО-ПРОСТРАНСТВЕННЫЙ КОМПЛЕКС «ПЕРЕХОД ГРАНИЦЫ» В РОМАНЕ Э.М. РЕМАРКА «ТРИУМФАЛЬНАЯ АРКА»

Sovremennye Issledovaniâ Socialʹnyh Problem, 2015
В статье анализируется сюжетно-пространственный комплекс перехода границы в эмигрантском романе Э.М. Ремарка «Триумфальная арка» на материале сюжетной линии главного героя.
Alice Sergeevna Porshneva
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Economic indicators of precision guidance in crop production in Agricultural Corporation Belgrade (PKB) [PDF]

FME Transactions, 2011
This paper examined the level of savings in the application of modern technical systems for satellite guidance and control over performing agricultural operations throughout the season.
Marković Dragan, Veljić Milan, Simonović Vojislav, Marković Ivana   +3 more
doaj  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source