Results 71 to 80 of about 4,496,478 (332)

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Analysis of Actantial Model in Suzanne Collins’ "The Hunger Games"

Rainbow: Journal of Literature, Linguistics and Culture, 2019
This study aims to analyze plot structure in Collins’ The Hunger Games. There are several questions that researcher wants to find, what the elements of plot are, how do the elements of plot compose the plot structure of the story, and what kind of plot ...
Uliya Dzikriya
doaj   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Antecknat: Berättandet och jakten mot nollpunkten

Kulturella Perspektiv, 2012
In this article I discuss the importance of plot not only in narratives but as a means of creating coherence and meaning in existence. There is a delicate balance of plot and characterization that is crucial in every narrative.
Anders Öhman
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

PSYCHOANALYTIC DIMENSIONS OF IVAN FRANKO’S GREAT PROSE OF 1887–1893 [PDF]

Вісник університету ім. А. Нобеля. Серія Філологічні науки
In the article, elements of mythopoetics in Ivan Franko’s great prose of 1887–1893 are explored using the methodology of psychoanalysis. The writer’s projection of prototypes (in Jungian terms) anticipated the discoveries of psychoanalysts in the ...
Svitlana M. Lutsak, Nataliia M. Vivcharyk   +1 more
doaj   +1 more source

Analogies in Yakut Olonkho and Tuvan Epos: Plot-Compositional Structure, Motives (based on the Epics “Nyurgun Bootur the Swift” by G. K. Orosin and “Hunan-Kara” Changchi-Khoo Oorzhak)

Научный диалог, 2020
The results of a comparative analysis of the texts of the Yakut and Tuvan epics in order to establish common features in the epic heritage of the Yakut and Tuvan peoples are presented in the article.
A. F. Koryakina
doaj   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Revisiting the Far Right Violent Extremist Threat: Violent Extremist Plot Success From 1948 Through 2017 [PDF]

, 2019
Far Right violent extremists have successfully executed over 150 violent plots in the United States in just the past decade. This exploratory study analyzed Far Right violent extremist plot success with the plot success of Islamist violent extremists ...
Austin, Jesse
core   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source