Results 141 to 150 of about 100,488 (302)

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

open access: yesEuropean Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

An approach to the evaluation of froth flotation reagents based on the use of the SWARA and WS-PLP methods [PDF]

open access: diamond, 2017
Dragiša Stanujkić   +3 more
openalex   +1 more source

Low cellular pyridoxal 5ʹ-phosphate levels decrease neurotransmitter and glutathione concentrations and increase susceptibility to hydrogen peroxide toxicity in SH-SY5Y cells

open access: yesClinical Nutrition Open Science
Summary: Objectives: Pyridoxal 5ʹ-phosphate (PLP) is an active and major form of vitamin B6 (VB6) in the body. PLP is essential as a cofactor for many enzymes involved in amino acid metabolism, and VB6 deficiency is associated with neurological ...
Nana Itoh   +4 more
doaj   +1 more source

Astrocyte MCT1 Expression Does Not Contribute to the Axonal Degenerative Phenotype Observed With Ubiquitous MCT1 Depletion

open access: yesGlia, Volume 74, Issue 2, February 2026.
Loss of astrocytic MCT1 does not cause late onset neurodegeneration. As ubiquitous MCT1 deletion causes axonal degeneration, oligodendrocytes and potentially other cells are more prominent drivers of MCT1‐mediated metabolic support of neurons. ABSTRACT We recently reported that the loss of oligodendrocyte metabolic support through the lactate and ...
Thomas Philips   +9 more
wiley   +1 more source

Modulating effects of Phellinus linteus polysaccharides on antioxidant capacity, immune function, intestinal function and microbiota in lipopolysaccharide-challenged broilers

open access: yesFrontiers in Microbiology
Phellinus linteus polysaccharides (PLP) have been shown to have beneficial effects on gut function and gut microbiota in animals. The intention of this study was to examine the effects of PLP on growth performance, immune function, intestinal barrier ...
Yang Li   +6 more
doaj   +1 more source

Assessment of the Retina of Plp-α-Syn Mice as a Model for Studying Synuclein-Dependent Diseases [PDF]

open access: gold, 2020
Kathrin Kaehler   +6 more
openalex   +1 more source

Suppressive CD8+ T‐Cells Are Key Cellular Mediators of Extracorporeal Photopheresis

open access: yesJournal of Clinical Apheresis, Volume 41, Issue 1, February 2026.
ABSTRACT Extracorporeal photopheresis (ECP) is a widely utilized immunomodulatory procedure with an incompletely defined mechanism. In graft‐versus‐host disease (GvHD) and transplant rejection, ECP is thought to induce immune tolerance by increasing regulatory CD4+ T‐cells, whereas in cutaneous T cell lymphoa it may enhance dendritic cell–mediated ...
Kai J. Rogers   +7 more
wiley   +1 more source

Dose‐Dependent Biphasic Effect of Palmitic Acid on Oligodendrocyte Function: Impacts on Viability, Differentiation, and Myelination

open access: yesJournal of Cellular Physiology, Volume 241, Issue 2, February 2026.
Schematic diagram showing dose‐dependent effects of PA in oligodendrocyte precursor MO3.13 cells and rodent organotypic hippocampal and cerebellar slice cultures. High doses lead to cell death accompanied by mitochondrial impairment, whereas low doses activate the Nrf2 antioxidant response and exert neuroprotective effect while balancing mitochondrial ...
Anna Palmiero   +12 more
wiley   +1 more source

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