The wmN1 Enhancer Region of the Mouse Myelin Proteolipid Protein Gene (mPlp1) is Indispensable for Expression of an mPlp1-lacZ Transgene in Both the CNS and PNS. [PDF]
Neurochem Res, 2020 Patyal P, Kockara NT, Wight PA.
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Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. [PDF]
, 2013 BackgroundTherapeutic strategies that induce effective neuroprotection and enhance intrinsic repair mechanisms are central goals for future treatment of multiple sclerosis (MS), as well as other diseases.
Hannsun, Gemmy +9 more
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Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2019 Introduction: Multiple sclerosis (MS) is a common neurodegenerative disease leading to the movement disorder and destruction of myelin. Physical exercise delays the onset of neurodegenerative processes by preventing the destruction of myelin and ...
Maryam Naghibzadeh +3 more
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CTLA-4: a negative regulator of autoimmune disease. [PDF]
, 1996 CTLA-4, a CD28 homologue expressed on activated T cells, binds with high affinity to the CD28 ligands, B7-1 (CD80) and B7-2 (CD86). This study was designed to examine the role of CTLA-4 in regulating autoimmune disease.
Bluestone, JA +4 more
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The fibrin-derived gamma377-395 peptide inhibits microglia activation and suppresses relapsing paralysis in central nervous system autoimmune disease. [PDF]
, 2007 Perivascular microglia activation is a hallmark of inflammatory demyelination in multiple sclerosis (MS), but the mechanisms underlying microglia activation and specific strategies to attenuate their activation remain elusive.
Adams, Ryan A +7 more
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NeuroImageRadiomics has made considerable progress in neurodegenerative diseases. However, previous studies only explored the feasibility of radiomics in clinical applications.
Yuting Yan +7 more
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High resolution neurochemical gold staining method for myelin in peripheral and central nervous system at the light- and electron-microscopic level [PDF]
, 2018 Myelin is a multilamellar membrane structure primarily composed of lipids and myelin proteins essential for proper neuronal function. Since myelin is a target structure involved in many pathophysiological conditions such as metabolic, viral, and ...
Eyupoglu, Ilker +3 more
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Journal of Basic Research in Medical Sciences, 2018 Introduction: By increasing the scientific focus on myelination, identifying factors that influence the myelination is an important goal for brain health.
Maryam Naghibzadeh +4 more
doaj
Anti-Myelin Proteolipid Protein Peptide Monoclonal Antibodies Recognize Cell Surface Proteins on Developing Neurons and Inhibit Their Differentiation. [PDF]
J Neuropathol Exp Neurol, 2019 Sobel RA +4 more
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