Results 41 to 50 of about 43,575 (246)

Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. [PDF]

, 2013
NG2 (nerve/glial antigen2)-expressing cells represent the largest population of postnatal progenitors in the central nervous system and have been classified as oligodendroglial progenitor cells, but the fate and function of these cells remain ...
Chung, S-H, Deng, W, Guo, F, Jiang, P, Pleasure, DE   +4 more
core   +2 more sources

Demyelination and axonal preservation in a transgenic mouse model of Pelizaeus-Merzbacher disease [PDF]

, 2010
It is widely thought that demyelination contributes to the degeneration of axons and, in combination with acute inflammatory injury, is responsible for progressive axonal loss and persistent clinical disability in inflammatory demyelinating disease.
Angus M. Brown, Fredrik I. Gruenenfelder, Ian R. Griffiths, Julia M. Edgar, Klaus‐Armin Nave, Laura Pratola, Mailis C. McCulloch, Paul Montague, Sebastian Thilemann, Siegal S, Williams MA   +10 more
core   +2 more sources

Proteolipid protein–deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling

Journal of Cell Biology, 2016
The authors show that central nervous system myelin lacking proteolipid protein (PLP) induces mitochondrial dysfunction, including altered motility, degeneration, and ectopic smooth endoplasmic reticulum interactions, leading to axonal structural defects
Xinghua Yin, G. Kidd, N. Ohno, G. Perkins, Mark Ellisman, Chinthasagar Bastian, S. Brunet, S. Baltan, B. Trapp   +8 more
semanticscholar   +1 more source

Neutron scattering studies on protein dynamics using the human myelin peripheral membrane protein P2

EPJ Web of Conferences, 2015
Myelin is a multilayered proteolipid membrane structure surrounding selected axons in the vertebrate nervous system, which allows the rapid saltatory conduction of nerve impulses.
Laulumaa Saara, Kursula Petri, Natali Francesca   +2 more
doaj   +1 more source

Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

eLife, 2018
Myelin, the insulating sheath around axons, supports axon function. An important question is the impact of mild myelin disruption. In the absence of the myelin protein proteolipid protein (PLP1), myelin is generated but with age, axonal function ...
Elizabeth A Gould, Nicolas Busquet, Douglas Shepherd, Robert M Dietz, Paco S Herson, Fabio M Simoes de Souza, Anan Li, Nicholas M George, Diego Restrepo, Wendy B Macklin   +9 more
doaj   +1 more source

Effect of Sox10 on remyelination of the hippocampus in cuprizone‐induced demyelinated mice

Brain and Behavior, 2020
Objective The low number of oligodendrocytes (OLs) in the hippocampus of patients with schizophrenia suggests that hippocampal demyelination is changed in this condition. Sox10 is expressed throughout OL development.
Yu Shao, Juan Ding, Qian‐xiong He, Quan‐rui Ma, Qiang Liu, Chun Zhang, Hao‐wen Lv, Juan Liu   +7 more
doaj   +1 more source

Effect Of Gender On T-Cell Proliferative Responses To Myelin Proteolipid Protein Antigens In Patients With Multiple Sclerosis And Controls [PDF]

, 2004
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Gender influences both susceptibility to MS, with the disease being more common in women, and the clinical course of disease, with an increased proportion of
Acarin, Amadori, Arnold, Baxevanis, Brinkman, Budinger, Burns, Burns, Burns, Cheng, Cutolo, Deibler, Derbinski, Fox, Goebels, Greer, Hammond, Hattori, Hauben, Huygen, Johnson, Judith M. Greer, Keegan, Kerlero de Rosbo, Lacroix-Desmazes, Lisak, Lombardi, Lovett-Racke, Macklin, Markovic-Plese, Mata, Melcangi, Michael P. Pender, Mock, Ng, O'Connor, Pamela A. McCombe, Pelfrey, Pender, Pender, Pender, Pender, Peter A. Csurhes, Poser, Runmarker, Sadatipour, Scholz, Schwartz, Seo, Stinissen, Takahashi, Tejada-Simon, Tejada-Simon, Tornwall, Trotter, Weinshenker, Weinstein, Willard, Zamvil   +58 more
core   +1 more source

The Multiple Roles of Myelin Protein Genes During the Development of the Oligodendrocyte

ASN Neuro, 2009
It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucleotide 3′-
Daniel Fulton, Pablo M Paez, Anthony T Campagnoni   +2 more
doaj   +1 more source

Evaluation of the diffusion MRI white matter tract integrity model using myelin histology and Monte-Carlo simulations

NeuroImage, 2020
Quantitative evaluation of brain myelination has drawn considerable attention. Conventional diffusion-based magnetic resonance imaging models, including diffusion tensor imaging and diffusion kurtosis imaging (DKI),11 AD: Axial diffusivity; AK: Axial ...
Zihan Zhou, Qiqi Tong, Lei Zhang, Qiuping Ding, Hui Lu, Laura E. Jonkman, Junye Yao, Hongjian He, Keqing Zhu, Jianhui Zhong   +9 more
doaj   +1 more source

The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. [PDF]

PLoS ONE, 2014
In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C de Jonge, Don C Lamb, Dick Hoekstra, Nicoletta Kahya, Wia Baron   +7 more
doaj   +1 more source