Results 51 to 60 of about 43,575 (246)

Characterization of the Expression of Vacuolar Protein Sorting 11 (Vps11) in Mammalian Oligodendrocytes

ASN Neuro, 2021
A founder mutation in human VPS11 ( Vacuolar Protein Sorting 11 ) was recently linked to a genetic leukoencephalopathy in Ashkenazi Jews that presents with the classical features of white matter disorders of the central nervous system (CNS).
Robert P. Skoff, Denise Bessert, Shreya Banerjee, Xixia Luo, Ryan Thummel   +4 more
doaj   +1 more source

In Silico Structural Analysis Predicting the Pathogenicity of PLP1 Mutations in Multiple Sclerosis

Brain Sciences, 2022
The X chromosome gene PLP1 encodes myelin proteolipid protein (PLP), the most prevalent protein in the myelin sheath surrounding the central nervous system.
Antigoni Avramouli, Marios G. Krokidis, Themis P. Exarchos, Panagiotis Vlamos   +3 more
doaj   +1 more source

Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]

, 2018
There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa, Kaufman, Daniel L, Olsen, Richard, Tian, Jide, Wallner, Martin   +4 more
core   +3 more sources

Methods for quantitative susceptibility and R2* mapping in whole post-mortem brains at 7T applied to amyotrophic lateral sclerosis

NeuroImage, 2020
Susceptibility weighted magnetic resonance imaging (MRI) is sensitive to the local concentration of iron and myelin. Here, we describe a robust image processing pipeline for quantitative susceptibility mapping (QSM) and R2* mapping of fixed post-mortem ...
Chaoyue Wang, Sean Foxley, Olaf Ansorge, Sarah Bangerter-Christensen, Mark Chiew, Anna Leonte, Ricarda AL Menke, Jeroen Mollink, Menuka Pallebage-Gamarallage, Martin R Turner, Karla L Miller, Benjamin C. Tendler   +11 more
doaj   +1 more source

Myelin‐specific T cells in animals with Japanese macaque encephalomyelitis

Annals of Clinical and Translational Neurology, 2021
Objective To determine whether animals with Japanese macaque encephalomyelitis (JME), a spontaneous demyelinating disease similar to multiple sclerosis (MS), harbor myelin‐specific T cells in their central nervous system (CNS) and periphery.
Aparna N. Govindan, Kristin S. Fitzpatrick, Minsha Manoharan, Ian Tagge, Steven G. Kohama, Betsy Ferguson, Samuel M. Peterson, Grayson S. Wong, William D. Rooney, Byung Park, Michael K. Axthelm, Dennis N. Bourdette, Larry S. Sherman, Scott W. Wong   +13 more
doaj   +1 more source

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]

, 2013
PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, S, Baker, D, Beyer, C, Gerritsen, W, Huizinga, R, Kipp, M, Peferoen-Baert, R, Pryce, G, Puentes, F, Reijerkerk, A, Ummenthum, K, van der Star, BJ, van der Valk, P, Victor, M   +13 more
core   +5 more sources

Oligodendrocytes in HIV-associated pain pathogenesis

Molecular Pain, 2016
Background Although the contributions of microglia and astrocytes to chronic pain pathogenesis have been a focal point of investigation in recent years, the potential role of oligodendrocytes, another major type of glial cells in the CNS that generates ...
Yuqiang Shi PhD, Jianhong Shu PhD, Zongsuo Liang PhD, Subo Yuan MD, PhD, Shao-Jun Tang PhD   +4 more
doaj   +1 more source

Assembly of CNS Myelin in the Absence of Proteolipid Protein [PDF]

Neuron, 1997
Two proteolipid proteins, PLP and DM20, are the major membrane components of central nervous system (CNS) myelin. Mutations of the X-linked PLP/DM20 gene cause dysmyelination in mouse and man and result in significant mortality. Here we show that mutant mice that lack expression of a targeted PLP gene fail to exhibit the known dysmyelinated phenotype ...
Klugmann, Matthias, Schwab, Markus H., Pühlhofer, Anja, Schneider, Armin, Zimmermann, Frank, Griffiths, Ian R., Nave, Klaus-Armin   +6 more
openaire   +2 more sources

Polyunsaturated fatty acids in the pathogenesis and treatment of multiple sclerosis [PDF]

, 2007
Epidemiological, biochemical, animal model and clinical trial data described in this overview strongly suggest that polyunsaturated fatty acids, particularly n-6 fatty acids, have a role in the pathogenesis and treatment of multiple sclerosis (MS).
Copeland, Esparza, Fitzgerald, Harbige, Harbige, Jones, Karpus, Laurence S. Harbige, Mohammad K. Sharief, Mokhtarian, Ovadia, Santambrogio, Selmaj, Serafina, Thompson, Thompson, Vartanian   +16 more
core   +2 more sources

Increased Gene Expression Leads to Massive Microglial Cell Activation and Inflammation Throughout the Brain

ASN Neuro, 2010
PMD (Pelizaeus-Merzbacher disease) is a rare neurodegenerative disorder that impairs motor and cognitive functions and is associated with a shortened lifespan.
Carrie L Tatar, Sunita Appikatla, Denise A Bessert, Ajaib S Paintlia, Inderjit Singh, Robert P Skoff   +5 more
doaj   +1 more source