Results 31 to 40 of about 43,575 (246)
Identification of potential functional peptides involved in demyelinating injury in the central nervous system [PDF]
PeerJ, 2023 Multiple sclerosis (MS) is a chronic inflammatory neurologic disease characterized by the demyelinating injury of the central nervous system (CNS).
Xiaohua Dong +6 more
doaj +2 more sources
Interaction of PLP with GFP-MAL2 in the human oligodendroglial cell line HOG. [PDF]
PLoS ONE, 2011 The velocity of the nerve impulse conduction of vertebrates relies on the myelin sheath, an electrically insulating layer that surrounds axons in both the central and peripheral nervous systems, enabling saltatory conduction of the action potential ...
Raquel Bello-Morales +6 more
doaj +1 more source
Metabolic Instability of Myelin Protein and Proteolipid Fractions [PDF]
European Journal of Biochemistry, 1971 Turnover of protein components of myelin in vivo was shown to be comparable to that of other brain proteins. Myelin was purified, to remove soluble contamination, by water shock (fraction M2) and centrifugation on sucrose and CsCl gradients. These methods gave two fractions, one of which consisted of characteristic myelin membranes free of visible ...
B, D'Monte, P, Mela, N, Marks
openaire +2 more sources
ASN Neuro, 2020 The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang +6 more
doaj +1 more source
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]
, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Antje Kroner +11 more
core +2 more sources
A Journey to the Conformational Analysis of T-Cell Epitope Peptides Involved in Multiple Sclerosis
Brain Sciences, 2020 Multiple sclerosis (MS) is a serious central nervous system (CNS) disease responsible for disability problems and deterioration of the quality of life. Several approaches have been applied to medications entering the market to treat this disease. However,
Catherine Koukoulitsa +4 more
doaj +1 more source
Nature Communications, 2023 Axon degeneration and functional decline in myelin diseases are often attributed to loss of myelin but their relation is not fully understood. Perturbed myelinating glia can instigate chronic neuroinflammation and contribute to demyelination and axonal ...
Janos Groh +12 more
doaj +1 more source
Critical role for prokineticin 2 in CNS autoimmunity [PDF]
, 2015 Objective: To investigate the potential role of prokineticin 2 (PK2), a bioactive peptide involved in multiple biological functions including immune modulation, in CNS autoimmune demyelinating disease.
ABOU HAMDAN M +16 more
core +1 more source
Lipid Composition of rat brain myelin in triethyl tin-induced edema
Journal of Lipid Research, 1971 Chronic triethyl tin intoxication was induced in young adult rats by oral feeding of triethyl tin sulfate. Progressively severe brain edema developed during the 3-month experimental period.
YOSHIKATSU ETO +2 more
doaj +1 more source
Very large G protein-coupled receptor 1 regulates myelin-associated glycoprotein via Gαs/Gαq-mediated protein kinases A/C. [PDF]
, 2013 VLGR1 (very large G protein-coupled receptor 1), also known as MASS1 (monogenic audiogenic seizure susceptible 1), is an orphan G protein-coupled receptor that contains a large extracellular N terminus with 35 calcium-binding domains.
Fu, Ying-Hui +3 more
core +1 more source