Human myelin proteolipid protein structure and lipid bilayer stacking. [PDF]
Cell Mol Life Sci, 2022 Abstract The myelin sheath is an essential, multilayered membrane structure that insulates axons, enabling the rapid transmission of nerve impulses. The tetraspan myelin proteolipid protein (PLP) is the most abundant protein of compact myelin in the central nervous system (CNS).
Ruskamo S +7 more
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Correlation Between Anti-Myelin Proteolipid Protein (PLP) Antibodies and Disease Severity in Multiple Sclerosis Patients With PLP Response-Permissive HLA Types [PDF]
Frontiers in Immunology, 2020 The most prominent pathological features of multiple sclerosis (MS) are demyelination and neurodegeneration. The exact pathogenesis of MS is unknown, but it is generally regarded as a T cell-mediated autoimmune disease.
Judith M. Greer +4 more
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A Myelin Proteolipid Protein-LacZ Fusion Protein Is Developmentally Regulated and Targeted to the Myelin Membrane in Transgenic Mice [PDF]
Journal of Cell Biology, 1993 Transgenic mice were generated with a fusion gene carrying a portion of the murine myelin proteolipid protein (PLP) gene, including the first intron, fused to the E. coli LacZ gene.
Duchala, Cynthia S. +3 more
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Biomedicines, 2022 Pelizaeus–Merzbacher Disease (PMD) is an inherited leukodystrophy affecting the central nervous system (CNS)—a rare disorder that especially concerns males. Its estimated prevalence is 1.45–1.9 per 100,000 individuals in the general population.
Guy Khalaf +5 more
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Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7. [PDF]
J Neurosci, 2011 CNS myelination by oligodendrocytes requires directed transport of myelin membrane components and a timely and spatially controlled membrane expansion. In this study, we show the functional involvement of the R-soluble N-ethylmaleimide-sensitive factor ...
Feldmann A +11 more
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Integrated stress response inhibition prolongs the lifespan of a Pelizaeus-Merzbacher disease mouse model by increasing oligodendrocyte survival [PDF]
Nature CommunicationsThe leukodystrophy Pelizaeus-Merzbacher disease (PMD) is caused by myelin protein proteolipid protein gene (PLP1) mutations. PMD is characterized by oligodendrocyte death and CNS hypomyelination; thus, increasing oligodendrocyte survival and enhancing ...
Yanan Chen +15 more
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Identification And Characterization Of A Second Encephalitogenic Determinant Of Myelin Proteolipid Protein (Residues 178-191) For SJL Mice [PDF]
Journal of Immunology, 1992 We previously described a synthetic peptide of myelin proteolipid protein (PLP), peptide 139-151, which induces experimental allergic encephalomyelitis in SJL/J (H-2s) mice.
Greer, J. M. +3 more
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Myelin-specific IL2 + T-cells are associated with last occurring relapse severity in relapsing–remitting multiple sclerosis [PDF]
Scientific ReportsAutoreactive T-cells against myelin are implicated in multiple sclerosis (MS) however, the functional relevance of IL2-producing central memory T-cells and IFNɣ-producing effector T-cells have not been assessed.
Rina Zilkha-Falb +3 more
doaj +2 more sources
Testing an inverse link between limbic alpha-synucleinopathy and myelin markers in mice and humans [PDF]
npj Parkinson's DiseaseIn Lewy body disease, alpha-synucleinopathic inclusions tend to develop in brain regions that extend long, thin, and unmyelinated projection fibers, but it is not known if this selective vulnerability is caused by poor myelination status.
Rachel N. Clark +10 more
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