Results 21 to 30 of about 43,575 (246)

Cysteine thioesters as myelin proteolipid protein analogues to examine the role of butyrylcholinesterase in myelin decompaction. [PDF]

ACS Chem Neurosci, 2011
Pottie IR, Higgins EA, Blackman RA, Macdonald IR, Martin E, Darvesh S.   +5 more
europepmc   +2 more sources

A Comprehensive Characterization of the Phospholipid and Cholesterol Composition of the Uncinate Fasciculus in the Human Brain: Evidence of Age-Related Alterations. [PDF]

J Neurochem
The uncinate fasciculus (UF), which serves to connect the anterior temporal lobe and the orbitofrontal cortex, is a highly understudied white matter fiber bundle. In this study, we characterized the fatty acid (FA) profile of myelin phospholipids in a fraction‐specific manner, as well as the cholesterol concentrations, in the human postmortem UF.
Perlman K, Chen CT, Smith ME, Kim J, Turecki G, Bazinet RP, Mechawar N.   +6 more
europepmc   +2 more sources

Microbial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies. [PDF]

Eur J Immunol
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Ceccon M, Ronchi F.
europepmc   +2 more sources

Overview of myelin, major myelin lipids, and myelin-associated proteins

Frontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
doaj   +1 more source

Endogenous Repair in Vanishing White Matter. [PDF]

Ann Neurol
[Color figure can be viewed at www.annalsofneurology.org] Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in ...
Plug BC, Man JHK, Breur M, Nutma E, Stellingwerff MD, Abbink TEM, Bugiani M, van der Knaap MS.   +7 more
europepmc   +2 more sources

Human Peripheral Myelin Protein 2 and Charcot-Marie-Tooth Disease or Structural Missense Variants Show Different Binding to Myelin-Like Lipid Monolayers. [PDF]

Chembiochem
We compare the membrane affinity of the P2 myelin protein and its Charcot–Marie–Tooth disease variants on a myelin‐like lipid monolayer. Epifluorescence microscopy reveals different two‐dimensional (2D) clustering and pressure‐dependent binding. Single‐point mutations in the P2 β‐barrel and α‐helix affect affinity.
Schöffmann FA, Imran MAS, Schwieger C, Hetland Ø, Jerschabek V, Raasakka A, Kursula P, Hinderberger D.   +7 more
europepmc   +2 more sources

Autophagic degradation of CNS myelin maintains axon integrity

Cell Stress, 2022
(Macro)autophagy is a major lysosome-dependent degradation mechanism which engulfs, removes and recycles unwanted cytoplasmic material, including damaged organelles and toxic protein aggregates.
Niki Ktena, Stefanos Ioannis Kaplanis, Irina Kolotuev, Alexandros Georgilis, Emmanouela Kallergi, Vasiliki Stavroulaki, Vassiliki Nikoletopoulou, Maria Savvaki, Domna Karagogeos   +8 more
doaj   +1 more source

Why Is MS a More Frequent Complication of EBV Infection in Females? [PDF]

Immunol Rev
ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Dunn SE, Alvarez-Sanchez N, Steinman L.
europepmc   +2 more sources

Dose-Dependent Biphasic Effect of Palmitic Acid on Oligodendrocyte Function: Impacts on Viability, Differentiation, and Myelination. [PDF]

J Cell Physiol
Schematic diagram showing dose‐dependent effects of PA in oligodendrocyte precursor MO3.13 cells and rodent organotypic hippocampal and cerebellar slice cultures. High doses lead to cell death accompanied by mitochondrial impairment, whereas low doses activate the Nrf2 antioxidant response and exert neuroprotective effect while balancing mitochondrial ...
Palmiero A, Pipicelli L, Rosa G, Sozio C, Punziano C, Raia M, Faraonio R, Vitolo G, Cammarota M, Boscia F, Menale C, Santillo M, Damiano S.   +12 more
europepmc   +2 more sources

Pelizaeus-Merzbacher Disease: A Case Report

Case Reports in Clinical Practice, 2020
Pelizaeus-Merzbacher Disease (PMD), as a rare genetically x-linked leukodystrophy, is a disorder of proteolipid protein expression in myelin formation. This disorder is clinically presented by neurodevelopmental delay and abnormal pendular eye movements.
Ghazaleh Jamalipour Soufi, Siavash Iravani   +1 more
doaj   +1 more source