Results 71 to 80 of about 43,575 (246)

Immunology of multiple sclerosis [PDF]

, 2007
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) leading to demyelination, axonal damage, and progressive neurologic disability.
A. Ascherio, A. Kutzelnigg, A. Kutzelnigg, B. Serafini, B.T. Sadatipour, C. Confavreux, C. Lucchinetti, C.F. Lucchinetti, C.H. Polman, C.S. Raine, D. Pohl, D. Zhou, E.L. Thacker, J. Correale, J.A. James, J.M. Greer, J.M. Greer, J.M. Greer, J.R. Berger, J.R. Oksenberg, Judith M. Greer, K.P. Wandinger, L.F. Barcellos, L.F. Barcellos, L.I. Levin, L.M. Villar, L.M. Villar, M. Sospedra, M.C. Diamond, M.P. Armengol, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.P. Pender, M.S. Freedman, Michael P. Pender, P.A. McCombe, R. Gold, R.A. Williamson, R.C. Collard, R.D. Henderson, S. Cepok, S. Cepok, S. Marconi, V.A. Lennon, W. Brück, W.B. Bias, Y. Qin, Z. Tabi   +52 more
core   +1 more source

Reduced Oligodendrocyte Density and Axonal Caliber Associated With Mitochondrial Alterations in the White Matter of Chronically‐Starved Mice

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe eating disorder associated with extreme weight loss, hyperactivity, and amenorrhea. Neuroimaging studies revealed brain atrophy and disruption of white matter integrity in the corpus callosum (CC) of patients with AN. However, the underlying pathophysiological mechanisms remain unclear.
Stephan Lang, Annelie Zimmermann, Kaja Dickert, Hanna Rupprecht, Julia Priebe, Fabienne Haberland, Hanna‐Sophia Henschke, Katharina Schuster, Marcus Frank, Linda Frintrop   +9 more
wiley   +1 more source

Immune-mediated genesis of multiple sclerosis

Journal of Translational Autoimmunity, 2020
Multiple sclerosis (MS) is widely acknowledged to be an autoimmune disease affecting the neuronal myelin structure of the CNS. Autoantigens recognized as the target of this autoimmune process are: myelin basal protein, anti-proteolipid protein ...
Salvatore Cavallo, MD, Specialist in Medical Genetics
doaj   +1 more source

Autopathogenic T helper cell type 1 (Th1) and protective Th2 clones differ in their recognition of the autoantigenic peptide of myelin proteolipid protein [PDF]

, 1997
We previously generated a panel of T helper cell 1 (Th1) clones specific for an encephalitogenic peptide of myelin proteolipid protein (PLP) peptide 139-151 (HSLGKWLGHPDKF) that induces experimental autoimmune encephalomyelitis (EAE) upon adoptive ...
Mercy Prabhu Das, Lindsay B. Nicholson, Judith M. Greer, Vijay K. Kuchroo, Pettinelli, Zamvil, Waldor, Brostoff, Ben-Nun, Kuchroo, Mosmann, Mosmann, Heinzel, Salagame, Romagnani, Baron, Kuchroo, Khoruts, Kuchroo, Nicholson, Kuchroo, Franco, McRae, van der Veen, Nicholson, Kuchroo, O'Garra, Janeway, Constant, Hosken, Paul, Fowell, Pfeiffer, Brocke, Katz, Pakala, Lafaille   +36 more
core   +2 more sources

Insertion of mutant proteolipid protein results in missorting of myelin proteins [PDF]

Annals of Neurology, 2003
AbstractTwo brothers with a leukodystrophy, progressive spastic diplegia, and peripheral neuropathy were found to have proteinaceous aggregates in the peripheral nerve myelin sheath. The patients' mother had only subclinical peripheral neuropathy, but the maternal grandmother had adult‐onset leukodystrophy.
VAURS BARRIERE C, WONG K, WEIBEL TD, ABU ASAB M, WEISS MD, KANESKI CR, MIXON TH, BONAVITA, Simona, CREVEAUX I, HEISS JD, TSOKOS M, GOLDIN E, QUARLES RH, BOESPFLUG TANGUY O, SCHIFFMANN R.   +14 more
openaire   +3 more sources

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Unusual Presentation of Pelizaeus-Merzbacher Disease: Female Patient with Deletion of the Proteolipid Protein 1 Gene

Case Reports in Genetics, 2015
Pelizaeus-Merzbacher disease (PMD) is neurodegenerative leukodystrophy caused by dysfunction of the proteolipid protein 1 (PLP1) gene on Xq22, which codes for an essential myelin protein.
Teva Brender, Donna Wallerstein, John Sum, Robert Wallerstein   +3 more
doaj   +1 more source

Making Myelin Basic Protein -from mRNA transport to localized translation

Frontiers in Cellular Neuroscience, 2013
In the central nervous system (CNS) of most vertebrates, oligodendrocytes enwrap neuronal axons with extensions of their plasma membrane to form the myelin sheath. Several proteins are characteristically found in myelin of which Myelin Basic Protein (MBP)
Christina eMüller, Nina Marita Bauer, Isabelle eSchäfer, Robin eWhite   +3 more
doaj   +1 more source

HLA Class II Genotype Does Not Affect the Myelin Responsiveness of Multiple Sclerosis Patients

Cells, 2020
Background: When aiming to restore myelin tolerance using antigen-specific treatment approaches in MS, the wide variety of myelin-derived antigens towards which immune responses are targeted in multiple sclerosis (MS) patients needs to be taken into ...
Judith Derdelinckx, Irene Nkansah, Naomi Ooms, Laura Van Bruggen, Marie-Paule Emonds, Liesbeth Daniëls, Tatjana Reynders, Barbara Willekens, Patrick Cras, Zwi N. Berneman, Nathalie Cools   +10 more
doaj   +1 more source

Increased circulating T cell reactivity to GM3 and GQ1b gangliosides in primary progressive multiple sclerosis [PDF]

, 2003
We have previously shown that patients with primary progressive multiple sclerosis (MS) have significantly elevated plasma levels of antibody to GM3 ganglioside compared to patients with relapsing-remitting MS, healthy subjects and patients with other ...
Acarin, Arnon, Baba, Bech, Beraud, Chiba, Endo, Feix, Greer, Greer, Ho, Ilyas, Judith M Greer, Kasai, Kaye D Hooper, Kracun, Kusunoki, Lublin, Markovic-Plese, Martin, Mata, McDonald, Michael F Good, Michael P Pender, Moody, Mullin, Nigel P Wolfe, Offner, Offner, Pamela A McCombe, Pender, Pender, Pender, Peter A Csurhes, Poser, Rees, Sadatipour, Shamshiev, Stevens   +38 more
core   +1 more source