Folia Neuropathologica, 2016 Multiple sclerosis (MS) is a human autoimmune neurodegenerative disease with an unknown etiology. Despite various therapies, there is no effective cure for MS.
Kaja Kasarełło +8 more
doaj +1 more source
Anti-CD20 therapy depletes activated myelin-specific CD8+ T cells in multiple sclerosis. [PDF]
, 2019 CD8+ T cells are believed to play an important role in multiple sclerosis (MS), yet their role in MS pathogenesis remains poorly defined. Although myelin proteins are considered potential autoantigenic targets, prior studies of myelin-reactive CD8+ T ...
Calabresi, Peter A +5 more
core
Conduction abnormalities are restricted to the central nervous system in experimental autoimmune encephalomyelitis induced by inoculation with proteolipid protein but not with myelin basic protein [PDF]
, 1994 Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease of the central nervous system (CNS) and can be induced by inoculation of animals with homogenized CNS tissue or highly purified myelin proteins such as myelin basic ...
Chalk, Jonathan B. +2 more
core +1 more source
MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential
MedComm – Future Medicine, Volume 5, Issue 1, March 2026.The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman +7 more
wiley +1 more source
Expression of a beta 1-related integrin by oligodendroglia in primary culture: evidence for a functional role in myelination. [PDF]
, 1994 We have investigated the expression of integrins by rat oligodendroglia grown in primary culture and the functional role of these proteins in myelinogenesis.
Malek-Hedayat, S, Rome, LH
core
Analogous amino acid sequences in myelin proteolipid and viral proteins [PDF]
FEBS Letters, 1986 Computer analysis of the intrinsic membrane protein, myelin proteolipid, shows strong sequence similarities between the putative extramembrane segments of the proteolipid protein and a number of viral proteins, several of which infect humans. These similarities are even more striking than those reported previously between viral proteins and the ...
Shaw, Shyh-Yu +2 more
openaire +2 more sources
Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination
CellsFailure of myelin regeneration by oligodendrocytes contributes to progressive decline in many neurological diseases. Here, using in vitro and in vivo rodent models, functional blockade, and mouse brain demyelination, we demonstrate that Sonic hedgehog ...
Mariagiovanna Russo +6 more
doaj +1 more source
Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes
ASN Neuro, 2016 Myelin is a special multilamellar structure involved in various functions in the nervous system. In the central nervous system, the oligodendrocyte (OL) produces myelin and has a unique morphology.
Reiji Yamazaki +3 more
doaj +1 more source
The development of a ε-polycaprolactone (PCL) scaffold for CNS repair [PDF]
, 2012 Potential treatment strategies for the repair of spinal cord injury (SCI) currently favour a combinatorial approach incorporating several factors, including exogenous cell transplantation and biocompatible scaffolds. The use of scaffolds for bridging the
Gelain F. +9 more
core +1 more source
Latent, Lytic, and Linked to Multiple Sclerosis—How EBV Drives Autoimmunity
European Journal of Immunology, Volume 56, Issue 2, February 2026.EBV latent and lytic genes uniquely contribute to Multiple Sclerosis development by various immunopathogenic mechanisms in susceptible hosts. Briefly, EBV infection shapes the B‐cell repertoire and promotes the oligoclonal expansion and subsequent CNS infiltration of T‐bet+CXCR3+ B cells, resulting in a cascade of immune dysregulation, CNS inflammation,
Fabienne Läderach +2 more
wiley +1 more source