Results 111 to 120 of about 43,575 (246)

In vitro acylation of rat brain myelin proteolipid protein.

Journal of Biological Chemistry, 1982
The incorporation of fatty acid into myelin proteolipid protein (PLP) was studied by incubating brain slices from 17-day-old rats with [9,10-3H]palmitic acid. Myelin proteins were analyzed by gel electrophoresis. As in vivo (Agrawal, H. C., Randle, C. L.,
L. Townsend, D. Agrawal, J. Benjamins, H. C. Agrawal   +3 more
semanticscholar   +1 more source

The Causal Relationship Between Atopic Dermatitis and Multiple Sclerosis: A Two‐Sample Mendelian Randomization Study

Dermatologic Therapy, Volume 2026, Issue 1, 2026.
Background Existing population‐based cohort studies have been devoted to find the correlation between atopic dermatitis (AD) and autoimmune diseases including multiple sclerosis (MS). However, whether there is a causal relationship between AD and MS remains elusive. Objective The study aims to assess the causal links between AD and MS.
Nuo Chen, Qianwei Zhuo, Min Luo, Jinger Lin, Haosong Zhang, Rong Li, Yue Han, Suraiya Saleem   +7 more
wiley   +1 more source

Pathogenic myelin-specific antibodies in multiple sclerosis target conformational proteolipid protein 1–anchored membrane domains

The Journal of Clinical Investigation, 2023
B cell clonal expansion and cerebrospinal fluid (CSF) oligoclonal IgG bands are established features of the immune response in multiple sclerosis (MS). Clone-specific recombinant monoclonal IgG1 Abs (rAbs) derived from MS patient CSF plasmablasts bound ...
Gregory P. Owens, Timothy J. Fellin, Adeline Matschulat, Vanessa Salas, Kristin L. Schaller, Katherine S. Given, Alanna M. Ritchie, Andre Navarro, Kevin Blauth, Ethan G. Hughes, Wendy B. Macklin, Jeffrey L. Bennett   +11 more
doaj   +1 more source

Monitoring retinal changes with optical coherence tomography predicts neuronal loss in experimental autoimmune encephalomyelitis. [PDF]

, 2019
BACKGROUND:Retinal optical coherence tomography (OCT) is a clinical and research tool in multiple sclerosis, where it has shown significant retinal nerve fiber (RNFL) and ganglion cell (RGC) layer thinning, while postmortem studies have reported RGC loss.
Aktas, Orhan, Albrecht, Philipp, Balk, Lisanne J, Cordano, Christian, Cruz-Herranz, Andrés, Dietrich, Michael, Fischer, Dietmar, Green, Ari J, Hallenberger, Angelika, Hartung, Hans-Peter, Hecker, Christina, Hilla, Alexander M, Ingwersen, Jens, Issberner, Andrea, Lehmann-Horn, Klaus, Levin, Marc H, von Gall, Charlotte, Yiu, Hao H, Zamvil, Scott S   +18 more
core   +1 more source

Glutamate Stimulates Oligodendrocyte Progenitor Migration Mediated via an αv Integrin/Myelin Proteolipid Protein Complex

Journal of Neuroscience, 2006
In the mammalian CNS, oligodendrocyte precursor cells (OPCs) express most neurotransmitter receptors, but their function remains unclear. The current studies suggest a physiological role for glutamate (AMPA and/or kainate) receptors in OPC migration ...
T. Gudz, H. Komuro, W. Macklin
semanticscholar   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Naturally Occurring Nervonic Acid Ester Improves Myelin Synthesis by Human Oligodendrocytes

Cells, 2019
The dysfunction of oligodendrocytes (OLs) is regarded as one of the major causes of inefficient remyelination in multiple sclerosis, resulting gradually in disease progression.
Natalia Lewkowicz, Paweł Piątek, Magdalena Namiecińska, Małgorzata Domowicz, Radosław Bonikowski, Janusz Szemraj, Patrycja Przygodzka, Mariusz Stasiołek, Przemysław Lewkowicz   +8 more
doaj   +1 more source

Induction of the myelin proteolipid protein (PLP) gene in C6 glioblastoma cells: functional analysis of the PLP promotor

Journal of Neuroscience, 1991
The terminal differentiation of postmitotic oligodendrocytes is marked by the induction of myelin-specific genes. In this report, we demonstrate that culture conditions that induce oligodendrocyte differentiation of glial progenitor cells also induce ...
K. Nave, Greg Lemke
semanticscholar   +1 more source

Temporal and partial inhibition of GLI1 in neural stem cells (NSCs) results in the early maturation of NSC derived oligodendrocytes in vitro. [PDF]

, 2019
BackgroundOligodendrocytes are a type of glial cells that synthesize the myelin sheath around the axons and are critical for the nerve conduction in the CNS.
Biswas, Sangita, Chechneva, Olga, Deng, Wenbin, Mayrhofer, Florian, Namchaiw, Poommaree, Wen, Han   +5 more
core