Results 121 to 130 of about 43,575 (246)

Preliminary Evidence of Increased Hippocampal Myelin Content in Veterans with Posttraumatic Stress Disorder. [PDF]

, 2015
Recent findings suggest the formation of myelin in the central nervous system by oligodendrocytes is a continuous process that can be modified with experience.
Chao, Linda L, Kaufer, Daniela, Neylan, Thomas C, Tosun, Duygu, Woodward, Steven H   +4 more
core   +1 more source

High Frequency of Autoreactive Myelin Proteolipid Protein–Specific T Cells in the Periphery of Naive Mice

Journal of Experimental Medicine, 2000
The autoreactive T cells that escape central tolerance and form the peripheral self-reactive repertoire determine both susceptibility to autoimmune disease and the epitope dominance of a specific autoantigen. SJL (H-2s) mice are highly susceptible to the
A. Anderson, L. Nicholson, K. Legge, V. Turchin, H. Zaghouani, V. Kuchroo   +5 more
semanticscholar   +1 more source

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

Journal of Immunology, 1993
We have derived a panel of CD4+, TCR-alpha/beta + T cell clones from SJL (H-2s) mice specific for an encephalitogenic determinant of myelin proteolipid protein (PLP) 139-151 (HSLGKWLGHPDKF).
Vijay K. Kuchroo, C. Martin, Judith M. Greer, Shyr-Te Ju, Raymond A. Sobel, M. Dorf   +5 more
semanticscholar   +1 more source

Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system

Neurobiology of Disease, 2007
Myelin degeneration in the central nervous system (CNS) is often associated with elevated numbers of T cells in brain and spinal cord (SC). In some degenerative diseases, this T cell immigration has no clinical relevance, in others, it may precede severe
Roland Grundtner, Klaus Dornmair, Ralf Dahm, Alexander Flügel, Naoto Kawakami, Manuel Zeitelhofer, Lucia Schoderboeck, Mikhail Nosov, Edgar Selzer, Martin Willheim, Michael Kiebler, Hartmut Wekerle, Hans Lassmann, Monika Bradl   +13 more
doaj   +1 more source

SJL Mice Infected with Acanthamoeba castellanii Develop Central Nervous System Autoimmunity through the Generation of Cross-Reactive T Cells for Myelin Antigens [PDF]

, 2014
We recently reported that Acanthamoeba castellanii (ACA), an opportunistic pathogen of the central nervous system (CNS) possesses mimicry epitopes for proteolipid protein (PLP) 139–151 and myelin basic protein 89–101, and that the epitopes induce ...
da Rocha-Azevedo, Bruno, Gangaplara, Arunakumar, Illes, Zsolt, Jamerson, Melissa, Marciano-Cabral, Francine, Massilamany, Chandirasegaran, Reddy, Jay, Sobel, Raymond A., Steffen, David, Zabad, Rana   +9 more
core   +1 more source

Identification of a New Exon in the Myelin Proteolipid Protein Gene Encoding Novel Protein Isoforms That Are Restricted to the Somata of Oligodendrocytes and Neurons

Journal of Neuroscience, 1999
The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM20 gene) has been of some interest because of its role in certain human demyelinating diseases, such as Pelizaeus-Merzbacher disease.
E. Bongarzone, C. Campagnoni, K. Kampf, E. Jacobs, V. Handley, V. Schonmann, A. Campagnoni   +6 more
semanticscholar   +1 more source

Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein. [PDF]

Sci Rep, 2020
Boyden AW, Brate AA, Karandikar NJ.
europepmc   +1 more source

Relapsing-remitting multiple sclerosis: advances in disease-modifying therapies [PDF]

, 2015
Multiple sclerosis is a demyelinating disease affecting the central nervous system. It is the most prevalent disabling neurological condition among young adults, with onset typically between 20 and 40 years of age. Infiltrating immune cells and microglia
Kay, Kathleen Alexandra
core   +1 more source

Study of POLR3A variants in a family trio suggests mutation-specific pathogenetic mechanisms: insights from integrative OMIC approaches

Cell Communication and Signaling
Background Hypomyelinating leukodystrophies (HLDs) are rare genetic neurodevelopmental disorders characterized by defective myelin formation. The genetic cause of these disorders has been ascribed to mutations in genes encoding myelin protein components,
Federica Rey, Alessia Casamassa, Samuele Di Cristofano, Letizia Esposito, Amata Amy Soriano, Letizia Messa, Clarissa Berardo, Mahsa Hazrati, Ilaria Ferrone, Maxime Bonnet, Fabio Bruschi, Ylenia Vaia, Massimo Marano, Enrico Bertini, Francesco Nicita, Davide Tonduti, Gianvincenzo Zuccotti, Angelo Luigi Vescovi, Domenico Raimondo, Jessica Rosati, Stephana Carelli, Cristina Cereda   +21 more
doaj   +1 more source

Jimpy mutant mouse: a 74-base deletion in the mRNA for myelin proteolipid protein and evidence for a primary defect in RNA splicing.

Proceedings of the National Academy of Sciences of the United States of America, 1986
K. Nave, C. Lai, F. Bloom, R. Milner
semanticscholar   +1 more source