Results 51 to 60 of about 24,895 (210)

Neonatal seizures: Advances in diagnosis and management

Epilepsia Open, EarlyView.
Abstract The International League Against Epilepsy (ILAE) created the ILAE Neonatal Task Force that classified neonatal seizures, defined neonatal epilepsy syndromes, and specified treatment guidelines. These frameworks, in addition to improved access to genetic testing and other recent advances, have revolutionized the diagnosis and management of ...
Elissa G. Yozawitz, Ronit M. Pressler, Eli M. Mizrahi   +2 more
wiley   +1 more source

To PLP or Not to PLP: Stereodivergent Transaminase-Catalyzed Reactions Directed by Kinetic and Thermodynamic Control

The Journal of Organic Chemistry
Selective catalysis is a key objective in organic synthesis, and reactions with differing kinetic and thermodynamic products present the opportunity for divergent reaction outcomes with a single catalyst. We report a biocatalytic method in which a single transaminase can form either cis or trans cyclohexylamines in high diastereoselectivity.
Madeline J. Fitzgerald, Xiaoyan Li, Dawei Peng, Chenlu Qin, Yuehan Sun, Chloe C. Wang, YeePui Yeung, Chi Nguyen, Hanna M. Key   +8 more
openaire   +2 more sources

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Snapshots of PLP‐substrate and PLP‐product external aldimines as intermediates in two types of cysteine desulfurase enzymes [PDF]

The FEBS Journal, 2019
Cysteine desulfurase enzymes catalyze sulfur mobilization from l‐cysteine to sulfur‐containing biomolecules such as iron‐sulfur (Fe‐S) clusters and thio‐tRNAs. The enzymes utilize the cofactor pyridoxal‐5'‐phosphate (PLP), which forms the external substrate‐ and product‐aldimines and ketimines during catalysis and are grouped into two types (I and II ...
Ryosuke Nakamura, Masahide Hikita, Shoko Ogawa, Yasuhiro Takahashi, Takashi Fujishiro   +4 more
openaire   +2 more sources

Reaction Rate Coefficients and Adduct Formation in the Cl Atom + (E)‐CF3CF2CH=CHCF2CF3 Reaction

International Journal of Chemical Kinetics, EarlyView.
ABSTRACT In this work, rate coefficients for the Cl‐atom + (E)‐CF3CF2CH═CHCF2CF3 (HFO‐153‐10mczz, F22E) gas‐phase reaction were measured as a function of temperature and pressure, k(243–323 K, 50–300 Torr), using a pulsed laser photolysis‐resonance fluorescence (PLP‐RF) technique.
Maria‐Areti I. Spanoudaki, Daniel Van Hoomissen, Vassileios C. Papadimitriou, James B. Burkholder   +3 more
wiley   +1 more source

Strategies for prevention of lower limb post-amputation pain: A clinical narrative review

Journal of Anaesthesiology Clinical Pharmacology, 2018
Postamputation limb pain or phantom limb pain (PLP) develops due to the complex interplay of peripheral and central sensitization. The pain mechanisms are different during the initial phase following amputation as compared with the chronic PLP.
Vanita Ahuja, Deepak Thapa, Babita Ghai
doaj   +1 more source

High‐Fat Diet Exacerbates Neuropathology in a Transgenic Mouse Model of Multiple System Atrophy

Movement Disorders, EarlyView.
Abstract Background Multiple system atrophy (MSA) is a rare and devastating neurodegenerative disorder. Accumulating clinical and preclinical evidence suggests that diabetes and insulin resistance may adversely influence MSA pathophysiology. Objective We investigated the potential association between diabetes, impaired glucose homeostasis, and MSA ...
Marie‐Laure Arotcarena, Anna Delamarre, Miguel Lopez‐Cuina, Hugo Martin, Elio Balpe, Xavier Fioramonti, Erwan Bezard, Wassilios G. Meissner   +7 more
wiley   +1 more source

Phantom Limb Pain Assessment Tools: A Literature Review Exploring Strengths and Limitations

Archives of Rehabilitation Research and Clinical Translation
Objective: To identify and categorize the pain instruments used to evaluate phantom limb pain (PLP), phantom limb sensations (PLSs), and residual limb pain (RLP) stratified by frequency of use, instrument completion time, and inclusion of descriptive ...
Alexandra N. Jenson, BS, Benjamin Branch, DO, Janelle M. Richard, BA, Aurora Quaye, MD   +3 more
doaj   +1 more source

A Survey of Pyridoxal 5′-Phosphate-Dependent Proteins in the Gram-Positive Model Bacterium Bacillus subtilis

Frontiers in Molecular Biosciences, 2019
The B6 vitamer pyridoxal 5′-phosphate (PLP) is a co-factor for proteins and enzymes that are involved in diverse cellular processes. Therefore, PLP is essential for organisms from all kingdoms of life.
Björn Richts, Jonathan Rosenberg, Fabian M. Commichau   +2 more
doaj   +1 more source

Fluorescence Enhancement of PLP for Application to HPLC

Agricultural and Biological Chemistry, 1988
In an HPLC analysis of vitamin B6 derivatives, the use of a reversed-phase ODS column in conjunction with a fluorescence detector has given promising results. However, PLP was rather insensitive to the analysis, making it difficult to obtain accurate results, especially in biological materials.
TSUGE, Haruhito, TOUKAIRIN-ODA, Toshikatsu, SHOJI, Takako, SAKAMOTO, Eiko, MORI, Mitsuaki, SUDA, Hiroyuki   +5 more
openaire   +1 more source