Results 101 to 110 of about 7,364 (206)

The effects of plumbagin on proliferation and metastasis in human liver cancer SK-hep-1 cells

open access: yesZhongguo aizheng zazhi, 2013
Background and purpose: Plumbagin is the main active components of traditional Chinese medicine of plumbago zeylanica. The present studies show that plumbagin has a killing effect on tumor cells.
曹晓淬   +4 more
doaj  

Effect of Plumbagin on growth inhibition and apoptosis of imatinib-resistant chronic myeloid leukemia

open access: yesHo Chi Minh City Open University Journal of Science - Engineering and Technology, 2017
Development of a new inhibitor of BCR-ABL tyrosine kinase is necessary for the treatment of chronic myeloid leukemia (CML) because of increasing resistance and tolerance to Imatinid efforts.
Bui Thi Kim Ly   +3 more
doaj  

Plumbagin Suppresses Pulmonary Fibrosis via Inhibition of p300 Histone Acetyltransferase Activity

open access: yes, 2020
Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial lung disease with a poor prognosis similar to that of malignancy. The causes of IPF are not clearly known, and there is no effective therapy to date.
손명현   +4 more
core   +1 more source

Plumbagin sensitizes breast cancer cells to tamoxifen-induced cell death through GRP78 inhibition and Bik upregulation

open access: yes, 2017
The glucose regulated protein 78 (GRP78) is a major chaperone of the endoplasmic reticulum, and a prosurvival component of the unfolded protein response. GRP78 is upregulated in many types of cancers, including breast cancer.
Anna Jaworska   +3 more
core   +1 more source

Plumbagin Inhibits Leptin-Induced Proliferation of Hepatic Stellate Cells via JAK2-STAT3 Pathway to Protect against Hepatic Fibrosis

open access: yes, 2013
Purpose: To investigate the protective effects of plumbagin against liver fibrosis and explore the influence of plumbagin on the proliferation of hepatic stellate cells (HSCs).
Zhao, Tiejian   +6 more
core   +4 more sources

Plumbagin inhibits the proliferation and survival of esophageal cancer cells by blocking STAT3-PLK1-AKT signaling

open access: yes, 2018
Esophageal squamous cell carcinoma (ESCC) is one of the deadliest cancers, and it requires novel treatment approaches and effective drugs. In the present study, we found that treatment with plumbagin, a natural compound, reduced proliferation and ...
Ting-Ting Liu   +11 more
core   +1 more source

Niosomal Plumbagin with Reduced Toxicity and Improved Anticancer Activity in BALB/C Mice

open access: yes, 1996
Plumbagin niosomes were prepared using a lipid layer hydration method, and drug entrapment was measured. The acute toxicity studies were conducted following treatment with free and niosomal plumbagin.
N Udupa, R A Raja Naresh, P Uma Devi
core   +1 more source

Unravelling the potent anti-oxidant and anti-inflammatory actions of plumbagin: A review of preclinical discoveries

open access: yesPharmacological Research - Modern Chinese Medicine
Introduction: Bioactive elements present in distinct medicinal plants and foods are appealing molecules for the evolution of novel medications for the treatment of multiple illnesses linked with inflammation and oxidative stress.
Aanchal Verma, Ahsas Goyal
doaj   +1 more source

Development of tumour-targeted delivery systems entrapping plumbagin for cancer therapy

open access: yes, 2019
This thesis was previously held under moratorium from 22 August 2019 until 22 August 2024.Plumbagin, a naphthoquinone mainly extracted from Plumbaginaceae plants, has been shown to have promising anti-cancer properties. However, its therapeutic potential
Sakpakdeejaroen, Intouch
core   +2 more sources

[Harmlessness of plumbagine in a biological experiment].

open access: yesVoprosy pitaniia, 1978
Plumbagine (2-methyl-5-oxy-1,4-naphtoquinone) did not have any essential effect on the general condition and dynamic changes in the body mass of albino rats, their blood coagulation system and fibrinolysis, the liver and renal functions and morphological structure of the internal organs. An analysis of the available data justify recommending plumbagine
openaire   +1 more source

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