Results 81 to 90 of about 7,364 (206)

Plumbagin analogs-synthesis, characterization, and antitubercular activity

open access: yesJournal of Advanced Pharmaceutical Technology & Research, 2014
Considering the emerging problem of drug resistance in tuberculosis, there is an urgent need of development of new analogs that are useful in curing drug resistant tuberculosis. In India, tuberculosis continues to remain one of the most pressing health problems.
Nishi Nayak   +2 more
openaire   +3 more sources

Advances in Novel Therapeutic Strategies for Pulmonary Arterial Hypertension

open access: yesCanadian Respiratory Journal, Volume 2026, Issue 1, 2026.
Pulmonary arterial hypertension (PAH) is a progressive, life‐threatening disease characterized by vascular remodeling, endothelial dysfunction, and chronic inflammation. Despite existing targeted therapies, long‐term outcomes remain poor, underscoring the need for more effective treatment.
Yalei Wang   +11 more
wiley   +1 more source

Isolation and characterization of plumbagin (5- hydroxyl- 2- methylnaptalene-1,4-dione) producing endophytic fungi Cladosporium delicatulum from endemic medicinal plants

open access: yesBiotechnology Reports, 2018
The rationale of the present study was to isolate and identify endophytic fungi from endemic medicinal plants in Eastern Ghats and screened for antimicrobial potential of isolated fungal crude extracts.
N. Venkateswarulu   +5 more
doaj   +1 more source

From Demyelination to Intervention: Natural Compounds as Emerging Therapeutic Targets in Multiple Sclerosis Neuroinflammation

open access: yesJournal of Immunology Research, Volume 2026, Issue 1, 2026.
Multiple sclerosis (MS) is a chronic immune‐mediated inflammatory demyelinating disease of the central nervous system (CNS), characterized by multifocal lesions, axonal damage, and progressive neurological dysfunction, imposing a heavy burden on patients and healthcare systems.
Zhiyong Long   +6 more
wiley   +1 more source

Ethnobotanical Evidence of Medicinal Plants Used for Peptic Ulcers in Tanzania: A Systematic Review

open access: yesScientifica, Volume 2026, Issue 1, 2026.
Medicinal plants (MPs) are essential to rural communities in low‐ and middle‐income countries. However, knowledge of the use of MPs for peptic ulcer disease (PUD) in Tanzania remains limited. This review aims to document the traditional knowledge and MPs used by Tanzanians to treat and manage PUD.
David Sylvester Kacholi, Nidhi Chaudhary
wiley   +1 more source

Autophagy and self-renewal after plumbagin treatment.

open access: yes, 2015
(A) Time dependent dynamics of CYTO-ID Green (CYTO-ID+, CYTO-ID++) after 2 μM plumbagin treatment. See autophagy peak at 8h-time point. (B) Time dependent dynamics of cell deaths after 2 μM plumbagin treatment; total CytoID staining (CYTO-ID+ and CYTO-ID+
Petr Babula (534976)   +8 more
core   +1 more source

MOESM2 of Fungal endophytes of Plumbago zeylanica L. enhances plumbagin content

open access: yes, 2019
Additional file 2: Figure S1. Estimation of the Plumbagin using LCMS-MS analysis, A: Calibration curve of Plumbagin, B: Chromatogram representing the standard Plumbagin, C: Chromatogram representing the mass and peak of the plumbagin in the methanolic ...
Avinash Ade (7356632)   +2 more
core   +1 more source

Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

open access: yes, 2010
Many phytochemicals function as noxious agents that protect plants against insects and other damaging organisms. However, at subtoxic doses, the same phytochemicals may activate adaptive cellular stress response pathways that can protect cells against a ...
Cutler, Roy G.   +12 more
core   +1 more source

Radiosensitizing effects of plumbagin in cervical cancer cells is through modulation of apoptotic pathway

open access: yes, 2008
Radiotherapy is the primary line of cancer treatment for cervical cancer and is known to induce cell death in tumors. Radiotherapy is however limited by the total dose that can be given without damaging normal tissue.
Nair, Sreekala   +4 more
core   +2 more sources

Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2

open access: yesMolecular Medicine, 2016
Sepsis is characterized by dysregulated systemic inflammation with release of early (for example, Interleukin (IL)-1β) and late (for example, HMGB1) proinflammatory mediators from macrophages. Plumbagin, a medicinal plant-derived naphthoquinone, has been
Zhaoxia Zhang   +7 more
doaj   +1 more source

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