Results 61 to 70 of about 7,364 (206)

Plumbagin ameliorates diabetic nephropathy via interruption of pathways that include NOX4 signalling. [PDF]

PLoS ONE, 2013
NADPH oxidase 4 (Nox4) is reported to be the major source of reactive oxygen species (ROS) in the kidneys during the early stages of diabetic nephropathy.
Rachel Yong, Xin-Ming Chen, Sylvie Shen, Swarna Vijayaraj, Qing Ma, Carol A Pollock, Sonia Saad   +6 more
doaj   +1 more source

A LAT1‐Compatible, Leadlike Tyrosine‐Naphthoquinone Conjugate With Anticancer Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT A L‐type amino acid transporter 1 (LAT1)‐compatible, anticancer‐active tyrosine‐naphthoquinone (NQ) conjugate was successfully developed. The conjugate was designed to exploit LAT1 overexpression in cancers with the goal of achieving selective cytotoxicity for cancerous over noncancerous cells.
Austin Seymour, Christian Peterson, Raymond Osafo, Abdullahi A. Ashimi, Dylan Williams, Laura Echezabal, Chelsea Carrier, Alysa Clarke, Clifford W. Padgett, Mark Vincent C. dela Cerna, Zheni Utic, Divine Wanduku, Nathaniel Shank, Karelle S. Aiken, Jannet Kocerha   +14 more
wiley   +1 more source

Resistance Modulation Action, Time-Kill Kinetics Assay, and Inhibition of Biofilm Formation Effects of Plumbagin from Plumbago zeylanica Linn

Journal of Tropical Medicine, 2019
Antimicrobial resistance (AMR) is a threat to the prevention and treatment of the increasing range of infectious diseases. There is therefore the need for renewed efforts into antimicrobial discovery and development to combat the menace.
Emmanuel B. A. Adusei, Reimmel K. Adosraku, James Oppong-Kyekyeku, Cedric D. K. Amengor, Yakubu Jibira   +4 more
doaj   +1 more source

Plumbagin Suppresses Breast Cancer Progression by Downregulating HIF-1α Expression via a PI3K/Akt/mTOR Independent Pathway under Hypoxic Condition

Molecules, 2022
Hypoxia-inducible factor-1α (HIF-1α) is a major transcriptional regulator that plays a crucial role in the hypoxic response of rapidly growing tumors. Overexpression of HIF-1α has been associated with breast cancer metastasis and poor clinical prognosis.
Supawan Jampasri, Somrudee Reabroi, Duangjai Tungmunnithum, Warisara Parichatikanond, Darawan Pinthong   +4 more
doaj   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

Interdisciplinary Medicine, Volume 4, Issue 2, March 2026.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang, Shiwen Deng, Fangfang Jin, Jiayao Qu, Xiang Fan, Peng Chen, Xinrong Fan   +6 more
wiley   +1 more source

Plumbagin recovery in field specimens of Drosophyllum lusitanicum (L.) Link

, 2008
The naphthoquinone plumbagin has a broad spectrum of biological activities. The aim of this study was to investigate the efficiency of two extraction methods (Soxhlet and ultrasound-assisted extraction) and three solvents (methanol, chloroform and ...
Romano, Anabela, Grevenstuk, Tomás, Gonçalves, Sandra, Nogueira, José Manuel F.   +3 more
core   +1 more source

Chemical Profiling, In Silico and In Vitro Studies to Identify Potential CDK2 and mTOR Inhibitor From Selaginella inaequalifolia (Hook. & Grev.) Spring Ethanolic Extracts

Chemistry &Biodiversity, Volume 23, Issue 2, February 2026.
ABSTRACT The current study is aimed to reveal the phytoprofile of Selaginella inaequalifolia (Hook. & Grev.) Spring using GC–MS and predict the drug properties, toxicity, biological properties of S. inaequalifolia ethanolic extracts (SiEE) using in silico methods and in vitro toxicity assays, namely, MTT and BSLB assay.
Johnson Marimuthu Alias Antonysamy, Sivaraman Arumugam, Robin Charles Antony Arulraj, Anne Wincy Jacob Thomas, Henrique D. M. Coutinho   +4 more
wiley   +1 more source

Anti-tumor effects of novel 5-O-acyl plumbagins based on the inhibition of mammalian DNA replicative polymerase activity.

PLoS ONE, 2014
We previously found that vitamin K3 (menadione, 2-methyl-1,4-naphthoquinone) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we focused on plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), and chemically synthesized
Moe Kawamura, Isoko Kuriyama, Sayako Maruo, Kouji Kuramochi, Kazunori Tsubaki, Hiromi Yoshida, Yoshiyuki Mizushina   +6 more
doaj   +1 more source

Impact of Formulation Ingredient Compatibility on Encapsulation of Hydrophobic Substances in Polymeric Nanocarriers Prepared by Nanoprecipitation

Macromolecular Materials and Engineering, Volume 311, Issue 2, February 2026.
Encapsulation of hydrophobic drugs in poly(lactic‐co‐glycolic) acid (PLGA) nanoparticles strongly depends on solvent and polymer compatibility. By linking Hansen solubility parameters with atomic force microscopy (AFM), scanning electron microscopy (SEM), and differential scanning calorimetry (DSC) analyses, the work reveals predictive markers of ...
Mark Sabura, Agnes‐Valencia Weiss, Svenja Pohl, Guido Kickelbick, Marc Schneider   +4 more
wiley   +1 more source

Plumbagin Suppresses the Invasion of HER2-Overexpressing Breast Cancer Cells through Inhibition of IKKα-Mediated NF-κB Activation.

PLoS ONE, 2016
HER2-overexpressing breast cancers account for about 30% of breast cancer occurrences and have been correlated with increased tumor aggressiveness and invasiveness.
Anna Kawiak, Anna Domachowska
doaj   +1 more source