Results 41 to 50 of about 7,364 (206)

Transferrin‐bearing liposomes entrapping plumbagin for targeted cancer therapy [PDF]

, 2019
The therapeutic potential of plumbagin, a naphthoquinone extracted from the officinal leadwort with anti-cancer properties, is hampered by its failure to specifically reach tumors at a therapeutic concentration after intravenous administration, without ...
Dufès, Christine, Somani, Sukrut, Partha Laskar, Laskar, Partha, Sakpakdeejaroen, Intouch, Intouch Sakpakdeejaroen, Margaret Mullin, Christine Dufès, Mullin, Margaret, Sukrut Somani   +9 more
core   +1 more source

Plumbagin Alleviates Intracerebroventricular-Quinolinic Acid Induced Depression-like Behavior and Memory Deficits in Wistar Rats

Molecules, 2022
Plumbagin, a hydroxy-1,4-naphthoquinone, confers neuroprotection via antioxidant and anti-inflammatory properties. The present study aimed to assess the effect of plumbagin on behavioral and memory deficits induced by intrahippocampal administration of ...
Mandeep Kumar Arora, Anish Ratra, Syed Mohammed Basheeruddin Asdaq, Ali A. Alshamrani, Abdulkhaliq J. Alsalman, Mehnaz Kamal, Ritu Tomar, Jagannath Sahoo, Jangra Ashok, Mohd Imran   +9 more
doaj   +1 more source

Effect of menadione and plumbagin on glutathione.

, 2013
The GSH and GSSG levels were expressed in nmols/mg of cell. Normal Growth refers to a non-stress condition while menadione or plumbagin stressed refers to cells stressed with 20 mM menadione or 7.0 μM plumbagin for 1 h, respectively.
Marcos Dias Pereira (375429), Diana Mariani (375424), Anita Dolly Panek (375426), Frederico Augusto Vieira Castro (375423), Elis Cristina Araújo Eleutherio (375428)   +4 more
core   +1 more source

Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

Plumbagin induces apoptotic in colonic cancer epithelial cells.

, 2013
a. Immunoblotting analysis of NFκB activation, Caspase-3 activation and cytochrome C release. Lane 1- Control HCT15; Lane 2- 15 µM plumbagin treated HCT15; Lane 3- 30 µM
Devaraj Halagowder (76131), Gayathri Srinivasan (308717), Lakshmi Baddi Reddi Subhadara (352254), Sakeena Sadullah Mohammed Sadullah (352252), Niranjali Devaraj Sivasitambaram (352255), Bharathi Raja Subramaniya (352251), Nimitha Davis (352253)   +6 more
core   +1 more source

CRM1 Is a Direct Cellular Target of the Natural Anti-cancer Agent Plumbagin

Journal of Pharmacological Sciences, 2014
Plumbagin, a naphthoquinone derived from the medicinal plant Plumbago zeylanica, has been shown to exert anti-cancer and anti-proliferative activities in vitro as well as in animal tumor models.
Xuejiao Liu, Mingshan Niu, Xiaoyu Xu, Wei Cai, Lingyu Zeng, Xiuping Zhou, Rutong Yu, Kailin Xu   +7 more
doaj   +1 more source

Metabolism of echitamine and plumbagin in rats

Journal of Biosciences, 1981
When administered to rats, echitamine was absorbed rapidly from the tissues and was detected in circulation within 30 min. The drug level reached a maximum value by 2 h and then decreased steadily. The drug had completely disappeared from the blood in 6 h.
B. Chandrasekaran, B. Nagarajan
openaire   +1 more source

Synthesis and Characterization of Juglone‐Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico

Journal of Applied Toxicology, EarlyView.
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Mustafa Öztatlıcı, Turan Birimoğlu, Semih Güler, Rukiye Betül Çolaksel, Mehmet Tahir Husunet, Mehmet Sönmez   +5 more
wiley   +1 more source

Two dimensional structure of plumbagin.

, 2014
The IUPAC name of the plumbagin is '5-hydroxy-2-methyl-1,4-naphthoquinone'. The carbon atoms are shown with the IUPAC numbering. The numbers are referred in the text wherever a particular atom of plumbagin is involved in molecular interaction with target
Mohd Rehan (198120), Adel M. Abuzenadah (528224), Shadma Parveen (528219), Ghazi A. Damanhouri (528223), Mohd Suhail (528221), Mohammad S. Jamal (528218), Mohd A. Beg (528220), Adeel G. A. Chaudhary (528222)   +7 more
core   +1 more source

Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges

The Chemical Record, EarlyView.
Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley   +1 more source