Investigating blood-brain barrier penetration and neurotoxicity of natural products for central nervous system drug development. [PDF]
Sci RepKato R +8 more
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Allelopathic compound 2-methoxy-1,4-naphthoquinone is broadly effective against pathogenic <i>Prototheca</i> species <i>in vitro</i> and <i>in vivo</i>. [PDF]
Antimicrob Agents ChemotherAliramezani A +5 more
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Complete chloroplast genome data of <i>Plumbago indica</i> L. a prominent medicinal plant. [PDF]
Data BriefZhang J +5 more
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The Loop-In Binding Mode of Dihydroorotase: Implications for Ligand Binding and Therapeutic Targeting. [PDF]
Int J Mol SciHuang CY.
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Plumbagin, a Biomolecule with (Anti)Osteoclastic Properties [PDF]
International Journal of Molecular Sciences, 2021 Plumbagin is a plant-derived naphthoquinone that is widely used in traditional Asian medicine due to its anti-inflammatory and anti-microbial properties. Additionally, plumbagin is cytotoxic for cancer cells due to its ability to trigger reactive oxygen species (ROS) formation and subsequent apoptosis.
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Plumbagin: A Potential Candidate for Future Research and Development
Current Pharmaceutical Biotechnology, 2022Abstract: Plumbagin has gained a lot of attention in research due to its various therapeutic actions. It is a secondary metabolite obtained from different plant families, such as Plumbaginaceae, Droseraceae, and Ebenceae. Various studies on plumbagin have revealed that it is a natural gift for mankind in treating chronic diseases, like cancer ...
Niyatee Thakor
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Distribution of plumbagin in the mplumbaginaceae
Phytochemistry, 1972Abstract Plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone) was found in roots and aerial parts of Dyerophytum africanum, Plumbago pearsonii and in roots of P. auriculata.
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C11H8O3, Mr=188.2, monoclinic, P21/a, a=19.067(3), b=7.057(2), c=13.370(3)A, β=91.12(2)°, V=1798.6A3, Z=8, Dm=1.37(3), Dx=1.390(1)Mgm-3, λ(MoKα)=0.7107A, μ=0.110mm-1, F(000)=784, T=298K, R=0.066 for 1426 reflections. There are two molecules in the asymmetric unit and they have slightly different geometry.
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Plumbagin: A Potential Anti-cancer Compound
Mini-Reviews in Medicinal Chemistry, 2021: Cancer is a deadly disease, which has significantly increased in both developed and developing nations. Treatment of cancer utilizing radiotherapy or chemotherapy actuates a few issues which incorporate spewing, sickness, unpalatable reactions, and so forth.
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Plumbagin suppresses endothelial progenitor cell-related angiogenesis in vitro and in vivo
Journal of Functional Foods, 2019 [[abstract]]Plumbagin, a naturally occurring naphthoquinone component isolated from the root of Plumbago zeylanica, reduces angiogenesis in human umbilical vein endothelial cells; whether plumbagin also has anti-angiogenic activity in human endothelial ...
Hsiang-Ping Lee +2 more
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