Results 171 to 180 of about 7,364 (206)

Plumbagin Suppresses α-MSH-Induced Melanogenesis in B16F10 Mouse Melanoma Cells by Inhibiting Tyrosinase Activity

International Journal of Molecular Sciences, 2017
Recent studies have shown that plumbagin has anti-inflammatory, anti-allergic, antibacterial, and anti-cancer activities; however, it has not yet been shown whether plumbagin suppresses alpha-melanocyte stimulating hormone (α-MSH)-induced melanin ...
Taek-In Oh, Yoon-Mi Lee, Ji-Hong Lim
exaly   +2 more sources

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The anthelmintic effect of plumbagin on Schistosoma mansoni

Experimental Parasitology, 2013
The anthelmintic effects of plumbagin (PB, 5-hydroxy-2-methyl-1,4-naphthoquinone) and praziquantel (PZQ) against adult Schistosoma mansoni in vitro were compared by estimating the relative motility (RM) values, survival indices (SI) and alterations of the tegument of flukes incubated in M-199 medium containing 1, 10 and 100 μg/ml of the drugs, at 1, 3,
Natcha, Lorsuwannarat, Naruwan, Saowakon, Pongrama, Ramasoota, Chaitip, Wanichanon, Prasert, Sobhon   +4 more
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Caging of plumbagin on silver nanoparticles imparts selectivity and sensitivity to plumbagin for targeted cancer cell apoptosis

Metallomics, 2014
Nano-caging of plumbagin for selective killing of cancer cells.
N, Duraipandy, Rachita, Lakra, Srivatsan, Kunnavakkam Vinjimur, Debasis, Samanta, Purna Sai, K, Manikantan Syamala, Kiran   +5 more
openaire   +2 more sources

Plumbagin and Its Role in Chronic Diseases

2016
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a plant-derived naphthoquinones obtained mainly from three families, including Plumbaginaceae, Droseraceae, and Ebenaceae. Plumbagin has exhibited its potential therapeutic benefits on numerous chronic diseases, i.e., breast cancer, non-small cell lung cancer, melanoma, ovarian, squamous cell ...
Pharkphoom, Panichayupakaranant, Md Iftekhar, Ahmad   +1 more
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SYNTHESIS OF ALKYL DERIVATIVES OF PLUMBAGIN

INDIAN DRUGS, 2013
A series of alkyl derivatives of plumbagin (2-methyl-5-hydroxy-1,4-naphthoquinone), analogous to Vitamin K, have been synthesized. Plumbagin reacts with carboxylic acid in presence of silver nitrate and ammonium peroxydisulphate to form its alkyl derivatives. The compounds synthesized were characterized by MS, IR, 1 H and 13C-NMR Spectroscopy.
G.M Ferreira, K.S. Laddha
openaire   +1 more source

Eine neue Plumbagin‐Synthese

Archiv der Pharmazie, 1988
AbstractAusgehend von 1,5‐Naphthalindiol (1) wird über die Mono‐Mannichbase 2 durch gezielte Acetylierung das 5‐Acetoxy‐Derivat 4 gewonnen, das durch Hydrogenolyse mit Pd–C die entsprechende Methylverbindung 7 ergibt. Die folgende Oxidation mit Fremy's Salz und anschließende Hydrolyse generiert das Plumbagin (10) in einer Gesamtausbeute von 33%.
Hans Möhrle, Hubertus Folttmann
openaire   +1 more source

Magnetite-Functionalized Plumbagin for Therapeutic Applications

ACS Sustainable Chemistry & Engineering, 2021
Synthesis of hybrid drug molecules from naturally occurring organic compounds has potential applications in several fields, including theranostics. In this work, we report the extraction of plumbagin from the roots of Plumbago indica L. and used it as a precursor to prepare plumbagin-functionalized magnetite nanoparticles (PFMNPs).
Samali Liyanaarachchi, Chayanika Padumadasa, Gayan Priyadarshana, Fransisco Carlos Robles Hernandez, Ayomi Dilhari, Onur Sahin, Sandali Lakshika, Gayan Wijesinghe, Manjula Weerasekera, Veranja Karunaratne, Zixing Wang, Ashokkumar Meiyazhagan, Nilwala Kottegoda, Pulickel M. Ajayan   +13 more
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Modulation of plumbagin production in Plumbago zeylanica using a single-chain variable fragment antibody against plumbagin

Plant Cell Reports, 2011
A single-chain variable fragment antibody (scFv) against plumbagin (PL) accumulated the PL production in the hairy roots of Plumbago zeylanica. Recombinant Agrobacterium rhizogenes (ATCC 15834) containing an scFv gene against PL (PL-scFv) were obtained through triparental mating and transformed into P.
Seiichi, Sakamoto, Waraporn, Putalun, Benyakan, Pongkitwitoon, Thaweesak, Juengwatanatrakul, Yukihiro, Shoyama, Hiroyuki, Tanaka, Satoshi, Morimoto   +6 more
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Antimutagenic and antioxidant properties of plumbagin and other naphthoquinones

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2013
The structure-function relationships of the naphthoquinone phytochemicals, plumbagin, juglone, and menadione, have been studied with regard to antimutagenic and antioxidant activities. Antimutagenicity of these compounds was assessed by the Ames test and RNA polymerase B (rpoB)-based rifampicin resistance assay.
Sanjeev, Kumar, Satyendra, Gautam, Arun, Sharma   +2 more
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Encapsulation of plumbagin using cyclodextrins to enhance plumbagin stability: computational simulation, preparation, characterization, and application

Journal of Inclusion Phenomena and Macrocyclic Chemistry, 2018
Encapsulation of plumbagin using cyclodextrins (CDs), including α-cyclodextrin (αCD), β-cyclodextrin (βCD), and γ-cyclodextrin (γCD) to form inclusion complexes was investigated to prevent the loss of plumbagin in pharmaceutical and nutraceutical products.
Pisanu Toochinda, Luckhana Lawtrakul, Arunporn Itharat   +2 more
exaly   +2 more sources