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Perspectives on medicinal properties of plumbagin and its analogs
Medicinal Research Reviews, 2010AbstractPlumbagin is one of the simplest plant secondary metabolite of three major phylogenic families viz. Plumbaginaceae, Droseraceae, and Ebenceae, and exhibits highly potent biological activities, including antioxidant, antiinflammatory, anticancer, antibacterial, and antifungal activities. Recent investigations indicate that these activities arise
Subhash, Padhye +4 more
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Plumbagin, Juglone, and Boropinal as Novel TRPA1 Agonists
Journal of Natural Products, 2016A series of seven oxyprenylated phenylpropanoids and naphthoquinones were tested regarding their ability to activate transient receptor potential ankyrin subtype 1 channel (TRPA1). Three of the assayed compounds, namely, boropinal (3), juglone (5), and plumbagin (7), acted as strong modulators of TRPA1 channels with EC50 values of 9.8, 1.7, and 0.5 μM,
Hill, K +6 more
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Ein weiterer Zugang zum Plumbagin
Archiv der Pharmazie, 1988AbstractDurch Aminomethylierung von 5‐Methoxy‐1‐naphthol (2) und anschließende Hydrogenolyse der Phenolmannichbase 6 zu 5‐Methoxy‐2‐methyl‐1‐naphthol (11) ist ein effektiver Zugang zum Plumbagin (13) gegeben.
Hans Möhrle, Hubertus Folttmann
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Network Pharmacology of Plumbagin for the Treatment of Psoriasis
Jordan Journal of Pharmaceutical SciencesBackground: Psoriasis skin disease brings attention to pharmacology studies; many traditional medicines from plants are defined as promising candidates for this disease treatment. Plumbagin is one candidate that has been proven for several decades for these issues.
Mitayani Purwoko +3 more
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Plumbagin relieves rheumatoid arthritis through nuclear factor kappa-B (NF-κB) pathway
Bioengineered, 2022Yiyuan Xi, Jujia Zheng, Xiangwei Xu
exaly
Hypolipidaemic and antiatherosclerotic effects of plumbagin in rabbits.
Indian journal of physiology and pharmacology, 1991Plumbagin (2-methyl-5-hydroxy, 1:4 naphthoquinone) isolated from the roots of Plumbago zeylanica when administered to hyperlipidaemic rabbits, reduced serum cholesterol and LDL-Chol. by 53 to 86 percent and 61 to 91 percent respectively. It lowered cholesterol/phospholipid ratio by 45.8 percent and elevates the decreased HDL-Chol significantly. Further,
I, Sharma, D, Gusain, V P, Dixit
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