Results 51 to 60 of about 23,427 (267)
The Gift of Insanity. The Rise and Fall of Cultures from a Psychiatric Perspective
Eidos. A Journal for Philosophy of Culture, 2018 This paper argues in favor of two related theses. First, due to a fundamental, biologically grounded world-openness, human culture is a biological imperative.
Marcin Moskalewicz +2 more
doaj +1 more source
A Criticism of the Theory of the Existential Overlapping between God and His Creatures in the Light of the Correct Definition of God’s Infiniteness [PDF]
پژوهشنامه فلسفه دین, 2018 Overlapping (tadākhul) between God and His creatures is a novel theory which aims to explain the relationship between God and His creatures. But, it seems that this theory is controversial.
Seyyed Mohsen Hendi +1 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Diaphonic pluralism: from truth pluralism to disagreement pluralism
Synthese, 2022 AbstractIn this paper, I offer a pluralistic framework for disagreement and I develop a strategy to account for the varieties of disagreement on the basis of the varieties of the truth across different domains of discourse. Truth-pluralism is thus sufficient for delivering pluralism about disagreement—that is, diaphonic pluralism.
openaire +2 more sources
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Pragmatism and Political Pluralism - Consensus and Pluralism [PDF]
Academicus International Scientific Journal, 2015 A pragmatist thinker like Nicholas Rescher deems the idea that social harmony must be predicated in consensus to be both dangerous and misleading. An essential problem of our time is the creation of political and social institutions that enable people to live together in peaceful and productive ways, despite the presence of not eliminable disagreements
openaire +3 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source