Results 51 to 60 of about 24,248 (267)
The Gift of Insanity. The Rise and Fall of Cultures from a Psychiatric Perspective
Eidos. A Journal for Philosophy of Culture, 2018 This paper argues in favor of two related theses. First, due to a fundamental, biologically grounded world-openness, human culture is a biological imperative.
Marcin Moskalewicz +2 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
A Criticism of the Theory of the Existential Overlapping between God and His Creatures in the Light of the Correct Definition of God’s Infiniteness [PDF]
پژوهشنامه فلسفه دین, 2018 Overlapping (tadākhul) between God and His creatures is a novel theory which aims to explain the relationship between God and His creatures. But, it seems that this theory is controversial.
Seyyed Mohsen Hendi +1 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Diaphonic pluralism: from truth pluralism to disagreement pluralism
Synthese, 2022 AbstractIn this paper, I offer a pluralistic framework for disagreement and I develop a strategy to account for the varieties of disagreement on the basis of the varieties of the truth across different domains of discourse. Truth-pluralism is thus sufficient for delivering pluralism about disagreement—that is, diaphonic pluralism.
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Pragmatism and Political Pluralism - Consensus and Pluralism [PDF]
Academicus International Scientific Journal, 2015 A pragmatist thinker like Nicholas Rescher deems the idea that social harmony must be predicated in consensus to be both dangerous and misleading. An essential problem of our time is the creation of political and social institutions that enable people to live together in peaceful and productive ways, despite the presence of not eliminable disagreements
openaire +3 more sources
FEBS Letters, EarlyView.Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley +1 more source