Results 61 to 70 of about 351,618 (311)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Sikap Adaptif dalam Konteks Keragaman Hidup Beragama
Dunamis: Jurnal Teologi dan Pendidikan Kristiani. The purpose of this article is to offer an adaptive attitude as a response to the reality of the diversity of religious life in Indonesia. Religious diversity in Indonesia, on the one hand, requires an attitude of acceptance towards the existence of ...
Dapot Damanik +3 more
doaj +1 more source
Entangled Religions, 2016 This essay first appeared in German in Magdalena Tzaneva, ed. Nachtflug der Eule: 150 Stimmen zum Werk von Niklas Luhmann. Gedenkbuch zum 15. Todestag von Niklas Luhmann (8. Dezember 1927 Lüneburg – 6. November 1998 Oerlinghausen). Berlin: LiDi EuropEdition (2013), 73–100. A shorter version of the essay was published in Hans-Georg Soeffner, and ...
openaire +4 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
A Theory of “Design by Research”; Mapping Experimentation in Architecture and Architectural Design
Ardeth, 2017 In an age of increased fragmentation, orientation and specialization, architectural research that aims at breaking new theoretical ground and introducing new techniques and methods of design makes sense only if it is able to formulate and make explicit ...
Marc Schoonderbeek
doaj
Perspectival Plurality, Relativism, and Multiple Indexing [PDF]
, 2018 In this paper I focus on a recently discussed phenomenon illustrated by sentences containing predicates of taste: the phenomenon of " perspectival plurality " , whereby sentences containing two or more predicates of taste have readings according to which
Zeman, Dan
core
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Plurality of Cases – Plurality of Values
Changing Societies & Personalities, 2021 Elena A. Stepanova
doaj +1 more source