Results 101 to 110 of about 173,671 (315)

Gain-of-function oncogenic mutations in TP53 enhance defined factor-mediated cellular reprogramming [PDF]

, 2011
Cancer is a disorder with various genetic and epigenetic alterations. Genetic alterations such as mutations, i.e., substitutions, amplifications, and deletions of nucleotide sequences, are largely irreversible, whereas epigenetic alterations can be ...
Kazuyoshi Yamamoto, Yoshiyuki Fujiwara, Hideshi Ishii, Yoshihiro Kano, Masaki Mori, Dyah Laksmi Dewi, Jeong Ho Moon, Shinpei Nishikawa, Yuichiro Doki   +8 more
core   +2 more sources

High‐Throughput Digital Decoding of Vascular Heterogeneity in Patient‐Specific Tumor Microenvironments

Advanced Healthcare Materials, EarlyView.
ABSTRACT Quantitative characterization of vascular heterogeneity in complex microphysiological systems (MPS), particularly within patient‐derived tumor microenvironments, remains a major challenge for scalable disease modeling and therapeutic evaluation.
Jungseub Lee, Wooju Park, Sujin Hyung, Sangmin Jung, Kyungho Lee, Junseok Jeon, Noo Li Jeon, Jeeyun Lee, Hye Ryoun Jang, Jihoon Ko   +9 more
wiley   +1 more source

Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells [PDF]

, 2012
Widera D, Hauser S, Kaltschmidt C, Kaltschmidt B. Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells. Anatomy Research International.
Hauser, Stefan, Kaltschmidt, Christian, Widera, Darius, Widera, Darius ; https://orcid.org/, Kaltschmidt, Barbara   +4 more
core   +2 more sources

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Microfabricated Devices for Adherent Stem Cell Culture [PDF]

, 2015
This thesis details the development of a system of microfabricated devices for the adherent culture of stem cells. The multipotency and self renewal of stem cells make them a potentially abundant source of valuable human cells, for both drug screening ...
Macown, RJ
core  

NuRD Suppresses Pluripotency Gene Expression to Promote Transcriptional Heterogeneity and Lineage Commitment [PDF]

, 2012
Transcriptional heterogeneity within embryonic stem cell (ESC) populations has been suggested as a mechanism by which a seemingly homogeneous cell population can initiate differentiation into an array of different cell types.
O'Shaughnessy, Aoife, Bertone, Paul, Latos, P, Hendrich, B, Leaford, Donna, Strouboulis, J, Brennecke, Philip, Kalkan, Tuezer, Costello, Ita, Brennecke, P, Nakagawa, Kentaro, Latos, Paulina, Hynes-Allen, Antony, Hynes-Allen, A, Behrens, A, Signolet, Jason, Mansfield, W, Kalkan, T, Reynolds, Nicola, Loos, R, Mosaku, O, Strouboulis, John, Behrens, Axel, Reynolds, N, O'Shaughnessy, A, Leaford, D, Bertone, P, Hendrich, Brian, Kalkan, Tüzer, Nakagawa, K, Loos, Remco, Humphreys, Peter, Mansfield, William, Mosaku, Olukunbi, Humphreys, P, Signolet, J   +35 more
core   +2 more sources

Bioprinting High‐Cell‐Density Cardiac Tissue Constructs With Sustained Contractile Function

Advanced Healthcare Materials, EarlyView.
Contractile cardiomyocytes in 3D culture provide insights into the behavior of the heart. Combining a 3D bioprinting approach with a multi‐electrode array allows the development of the 3D culture to be monitored over time, and matured cultures allow the effect of drugs on cardiac function to be modelled, replicating effects seen in clinical application.
Priscila Melo, Wing Tai Tung, Harvey Lewis, Kavin Hettiarachchilage, Babis Tzivelekis, Rolando Berlinguer‐Palmini, Ana Marina Ferreira, Jason Gill, Kenneth Dalgarno   +8 more
wiley   +1 more source

Characteristic Expression of Major Histocompatibility Complex and Immune Privilege Genes in Human Pluripotent Stem Cells and Their Derivatives [PDF]

, 2017
Pluripotent stem cells, including human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs), have been regarded as useful sources for cell-based transplantation therapy.
Chen, Hsin-Fu;Yu, Chun-Ying;Chen, Mei-Jou;Chou, Shiu-Huey;Chiang, Ming-Shan;Chou, Wen-Hsi;Ko, Bor-Sheng;Huang, Hsiang-Po;Kuo, Hung-Chih;Ho, Hong-Nerng, 陳美州;柯博升;何弘能;陳信孚   +1 more
core   +1 more source

Efficient induction of EPSCs via episomal reprogramming: a functionally equivalent yet transcriptionally specialized alternative to EPSCs

Stem Cell Research
This study establishes a streamlined one-step strategy using optimized episomal plasmid reprogramming to directly generate extended pluripotent stem cells (dEPSCs) from human peripheral blood mononuclear cells (PBMCs), bypassing the induced pluripotent ...
Ran Zheng, Mengna Zhang, Yanhong Cheng, Junjie Wen, Xiyu Zhao, Dan Xiao, Jingyu Xu, Ke Pei, Liang Wang, Jie Xu, Jian Zhang, Cheguo Cai, Yunfeng Gao   +12 more
doaj   +1 more source

Effects of reprogramming on genomic imprinting and the application of pluripotent stem cells

Stem Cell Research, 2019
Pluripotent stem cells are considered to be the ideal candidates for cell-based therapies in humans. In this regard, both nuclear transfer embryonic stem (ntES) cells and induced pluripotent stem (iPS) cells are particularly advantageous because patient ...
Xiajun Li, Max Jiahua Li, Yang Yang, Yun Bai   +3 more
doaj   +1 more source