Results 101 to 110 of about 1,024,717 (349)

Pluripotency of embryo-derived stem cells from rodents, lagomorphs, and primates: Slippery slope, terrace and cliff

Stem Cell Research, 2017
The diverse cell states and in vitro conditions for the derivation and maintenance of the mammalian embryo-derived pluripotent stem cells raise the questions of whether there are multiple states of pluripotency of the stem cells of each species, and if ...
Pierre Savatier, Pierre Osteil, Patrick P.L. Tam   +2 more
doaj   +1 more source

Transcriptionally Active HERV-H Retrotransposons Demarcate Topologically Associating Domains in Human Pluripotent Stem Cells

Nature Genetics, 2019
Chromatin architecture has been implicated in cell type-specific gene regulatory programs, yet how chromatin remodels during development remains to be fully elucidated.
Yanxiao Zhang, Ting Li, Sebastian Preissl, Maria Luisa Amaral, Jonathan D. Grinstein, Elie N. Farah, Eugin Destici, Yunjiang Qiu, Rong Hu, Ah Young Lee, Sora Chee, Kaiyue Ma, Z. Ye, Quan-sheng Zhu, Hui Huang, Rongxin Fang, Leqian Yu, J. I. Izpisúa Belmonte, Jun Wu, S. Evans, N. Chi, B. Ren   +21 more
semanticscholar   +1 more source

Assembly of Cell‐Seeded 3D Printed Hydrogel Modules with Perfusable Channel Networks

Advanced Functional Materials, EarlyView.
Macroscale assembly was utilized to prepare perfusable tissue constructs from individually 3D printed hydrogel modules with embedded branched channel networks and port arrays for cell seeding. Novel multi‐material bioreactors were fabricated to facilitate the gluing of individual modules and the perfusion culture of assembled modular constructs seeded ...
Zachary J. Geffert, Daniel Fougnier, Bo Van Durme, Jenna Grutzmacher, Ryan Clarke, Susan Cao, Zhenghao Li, Ujjwal Aryal, Jason A. Horton, Sandra Van Vlierberghe, Pranav Soman   +10 more
wiley   +1 more source

c-Jun inhibition mitigates chemotherapy-induced neurotoxicity in iPSC-derived sensory neurons

Cell Death Discovery
Chemotherapy-induced peripheral neuropathy (CIPN) affects up to two-thirds of cancer patients undergoing cytotoxic chemotherapy. Here, we used human iPSC-derived sensory neurons (iPSC-DSN) to model CIPN in vitro.
Lois Hew, Smilla K. Maierhof, Andranik Ivanov, Dieter Beule, Valeria Fernandez Vallone, Harald Stachelscheid, Silke Frahm, Narasimha Swamy Telugu, Matthias Endres, Wolfgang Boehmerle, Petra Huehnchen, Christian Schinke   +11 more
doaj   +1 more source

DIRECTED RE-PROGRAMMING OF SOMATIC CELLS: ADVANTAGES AND LIMITATIONS OF INDUCED PLURIPOTENT STEM CELLS (REVIEW)

Сибирский научный медицинский журнал, 2019
Stem cells are divided into embryonic and adult stem cells. The relevance of the use of stem cells in clinical practice has received new evidence in recent years however, the methods of obtaining stem cells for medical purposes cause ethical rejection ...
A. V. Korel, S. B. Kuznetsov
doaj   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Development of a practical sandwich assay to detect human pluripotent stem cells using cell culture media

Regenerative Therapy, 2017
Human pluripotent stem cells are considered to be ideal cell sources for regenerative medicine, but their clinical and industrial application is hindered by their tumorigenic potential.
Hiroaki Tateno, Keiko Hiemori, Kazunari Hirayasu, Nagako Sougawa, Masakazu Fukuda, Masaki Warashina, Makoto Amano, Taku Funakoshi, Yoshifusa Sadamura, Shigeru Miyagawa, Atsuhiro Saito, Yoshiki Sawa, Tomoko Shofuda, Miho Sumida, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano, Yasuko Onuma, Yuzuru Ito, Makoto Asashima, Jun Hirabayashi   +20 more
doaj   +1 more source

Induced pluripotent stem (iPS) cells from human fetal stem cells [PDF]

, 2016
Pluripotency defines the ability of stem cells to differentiate into all the lineages of the three germ layers and self-renew indefinitely. Somatic cells can regain the developmental potential of embryonic stem cells following ectopic expression of a set
Guillot, PV
core   +1 more source

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

Nature Communications, 2020
Induced pluripotent stem cell (iPSC)-derived dopaminergic (DA) neurons are an expected source for cell-based therapies for Parkinson’s disease (PD).
D. Doi, Hiroaki Magotani, Tetsuhiro Kikuchi, Megumi Ikeda, Satoe Hiramatsu, Kenji Yoshida, Naoki Amano, Masaki Nomura, Masafumi Umekage, A. Morizane, J. Takahashi   +10 more
semanticscholar   +1 more source

Mechanical and Electrical Phenotype of hiPSC‐Cardiomyocytes on Fibronectin‐Based Hydrogels

Advanced Healthcare Materials, EarlyView.
We introduce fibronectin‐based PEG hydrogels with controlled rigidity to enable the culture of iPSC‐derived cardiomyocytes. These substrates offer an alternative to the current culture of these cells on fibronectin‐coated glass, providing enhanced structural and functional behavior. The system provides a more physiologically relevant platform to assess
Ana Da Silva Costa, Lineta Stonkute, Sara Trujillo, Mariana Azevedo Gonzalez Oliva, Francis Burton, Matthew J. Dalby, Oana Dobre, Godfrey Smith, Manuel Salmeron‐Sanchez   +8 more
wiley   +1 more source