Results 121 to 130 of about 1,024,717 (349)

Photoreceptor Outer Segment-like Structures in Long-Term 3D Retinas from Human Pluripotent Stem Cells. [PDF]

, 2017
The retinal degenerative diseases, which together constitute a leading cause of hereditary blindness worldwide, are largely untreatable. Development of reliable methods to culture complex retinal tissues from human pluripotent stem cells (hPSCs) could ...
Angueyra, Juan M, Ball, John, Grebe, Rhonda, Jones, Bryan W, Kim, Catherine, Li, Wei, Maruotti, Julien A, Sripathi, Srinivasa R, Wahlin, Karl J, Zack, Donald J   +9 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Patient and Disease-Specific Induced Pluripotent Stem Cells for Discovery of Personalized Cardiovascular Drugs and Therapeutics. [PDF]

, 2020
Human induced pluripotent stem cells (iPSCs) have emerged as an effective platform for regenerative therapy, disease modeling, and drug discovery.
Chandy, Mark, Paik, David T, Wu, Joseph C   +2 more
core  

ETV2 Mediated Differentiation of Human Pluripotent Stem Cells Results in Functional Endothelial Cells for Engineering Advanced Vascularized Microphysiological Models

Advanced Healthcare Materials, EarlyView.
A robust method to generate functional human iPSC‐derived endothelial cells using inducible ETV2 expression. These cells self‐organize into stable, lumenized microvascular networks within microfluidic chips, surpassing conventional differentiation methods.
Shun Zhang, Zhengpeng Wan, Lei Wang, Caihong Wu, Junkai Zhang, Sarah Spitz, Xun Wang, Marie A. Floryan, Mark F. Coughlin, Francesca M. Pramotton, Liling Xu, Ron Weiss, Roger D. Kamm   +12 more
wiley   +1 more source

Mapping the Cerebral Organoid Landscape: A Systematic Review of Preclinical 3D Models in Neuroscience

Advanced Healthcare Materials, EarlyView.
Cerebral organoids are transforming brain research, yet the field remains fragmented. This comprehensive systematic review maps 738 studies published between 2014 and 2024 to uncover trends, gaps, and opportunities across neuroscience. Introducing OrganoidMap—an interactive, open‐access platform to explore and compare models—this work enables ...
Anna Wolfram, Vanessa Arnold, Maik Wolfram‐Schauerte, Anastassiya Moskalchuk, Caroline Trust, Marie Vontz, Mona Scheurenbrand, Vijayasarathy Sampath‐Kumar, Sogand Ahari, Carlos Romero‐Nieto, Lisa Sevenich   +10 more
wiley   +1 more source

Comprehensive insight into chicken germline cells: A review

Poultry Science
Genetic information is propagated in the progeny through germ cells. The stem cells which are precursors of these germ cells have the ability of self-renewal and can give rise to pluripotent stem cells under favorable conditions.
Malik Ahsan Ali, Kai Jin, Guohong Chen, Xiaomeng Pei, Bichun Li   +4 more
doaj   +1 more source

Identification and Characterization of a LIF-STAT3/Activin-Smad2/3 Dual Responsive Pluripotent Stem Cell State

, 2011
The medical and bioindustrial applications of pluripotent stem cells rely on our understanding of their biology. Pluripotent stem cell lines derived from embryos in different stages depend on distinct signalling pathways.
Chang, Kuo-Hsuan, Chang, Kuo-Hsuan
core   +1 more source

Association of Human iPSC Gene Signatures and X Chromosome Dosage with Two Distinct Cardiac Differentiation Trajectories. [PDF]

, 2019
Despite the importance of understanding how variability across induced pluripotent stem cell (iPSC) lines due to non-genetic factors (clone and passage) influences their differentiation outcome, large-scale studies capable of addressing this question ...
Banovich, Bao, Barakat, Bargehr, Bruck, Burridge, D'Antonio, DeBoever, Desai, Diogenes, Dubois, Gittenberger-de Groot, GTEx Consortium, Guadix, Iyer, Kilpinen, Kim, Li, Lian, Lian, Luo, Mo, Newman, Paik, Panopoulos, Panopoulos, Perez-Pomares, Strober, Subramanian, Tatler, Tohyama, Tukiainen, Wang, Witty, Zhao   +34 more
core   +2 more sources

The potential and limitations of induced pluripotent stem cells to achieve wound healing

Stem cell research & therapeutics, 2019
Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to dysregulation secondary to local and systemic
J. Gorecka, Valentyna Kostiuk, A. Fereydooni, Luis Gonzalez, Jiesi Luo, Biraja C. Dash, T. Isaji, Shun Ono, Shirley Liu, Shin-Rong Lee, Jianbiao Xu, Jia Liu, R. Taniguchi, Bogdan Yastula, H. Hsia, Y. Qyang, A. Dardik   +16 more
semanticscholar   +1 more source

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source